Diseases of muscle that are caused by pathological interactions between muscle and the
immune system are devastating, but rare. However, muscle injuries that involve trauma and …

Skeletal muscles are essential for vital functions such as movement, postural support,
breathing, and thermogenesis. Muscle tissue is largely composed of long, postmitotic …

The mechanisms underlying gene repression and silencers are poorly understood. Here we
investigate the hypothesis that H3K27me3-rich regions of the genome, defined from clusters …

Oxygen sensing is central to metazoan biology and has implications for human disease.
Mammalian cells express multiple oxygen-dependent enzymes called 2-oxoglutarate (OG) …

Organisms require an appropriate balance of stability and reversibility in gene expression
programmes to maintain cell identity or to enable responses to stimuli; epigenetic regulation …

Chromatin modification by Polycomb proteins provides an essential strategy for gene
silencing in higher eukaryotes. Polycomb repressive complexes (PRCs) silence key …

Mononucleosomes, the basic building blocks of chromatin, contain two copies of each core
histone. The associated posttranslational modifications regulate essential chromatin …