Antibiotic resistance in the patient with cancer: Escalating challenges and paths forward

AK Nanayakkara, HW Boucher… - CA: a cancer journal …, 2021 - Wiley Online Library
Infection is the second leading cause of death in patients with cancer. Loss of efficacy in
antibiotics due to antibiotic resistance in bacteria is an urgent threat against the continuing …

How I prevent infections in patients receiving CD19-targeted chimeric antigen receptor T cells for B-cell malignancies

JA Hill, SK Seo - Blood, The Journal of the American Society of …, 2020 - ashpublications.org
Adoptive immunotherapy using B-cell–targeted chimeric antigen receptor (CAR)-modified T
cells to treat hematologic malignancies is transforming cancer care for patients with …

Optimal management of neutropenic fever in patients with cancer

AJ Zimmer, AG Freifeld - Journal of oncology practice, 2019 - ascopubs.org
Febrile neutropenia remains an important complication of treatment with cytotoxic
chemotherapy. It is often the first and sometimes the only sign or symptom of infection in this …

8th European Conference on Infections in Leukaemia: 2020 guidelines for the use of antibiotics in paediatric patients with cancer or post-haematopoietic cell …

T Lehrnbecher, D Averbuch, E Castagnola… - The Lancet …, 2021 - thelancet.com
Paediatric patients with cancer and those undergoing haematopoietic cell transplantation
are at high risk of bacterial infections. The 8th European Conference on Infections in …

Levofloxacin prophylaxis in patients with newly diagnosed myeloma (TEAMM): a multicentre, double-blind, placebo-controlled, randomised, phase 3 trial

MT Drayson, S Bowcock, T Planche, G Iqbal… - The lancet …, 2019 - thelancet.com
Background Myeloma causes profound immunodeficiency and recurrent, serious infections.
Around 5500 new cases of myeloma are diagnosed per year in the UK, and a quarter of …

Primary prophylaxis of bacterial infections and Pneumocystis jirovecii pneumonia in patients with hematologic malignancies and solid tumors: 2020 updated …

AY Classen, L Henze, M von Lilienfeld-Toal… - Annals of …, 2021 - Springer
Hematologic and oncologic patients with chemo-or immunotherapy-related
immunosuppression are at substantial risk for bacterial infections and Pneumocystis jirovecii …

Febrile neutropenia in acute leukemia. Epidemiology, etiology, pathophysiology and treatment

BA Hansen, Ø Wendelbo, Ø Bruserud… - … of hematology and …, 2019 - pmc.ncbi.nlm.nih.gov
Acute leukemias are a group of aggressive malignant diseases associated with a high
degree of morbidity and mortality. An important cause of both the latter is infectious …

Short versus extended treatment with a carbapenem in patients with high-risk fever of unknown origin during neutropenia: a non-inferiority, open-label, multicentre …

NA de Jonge, JJ Sikkens, S Zweegman… - The Lancet …, 2022 - thelancet.com
Background Early antibiotic discontinuation has been advocated in haematology patients
with fever of unknown origin during chemotherapy-induced neutropenia, but its safety is …

Efficacy of antibiotic prophylaxis in patients with cancer and hematopoietic stem cell transplantation recipients: a systematic review of randomized trials

G Egan, PD Robinson, JPD Martinez… - Cancer …, 2019 - Wiley Online Library
Purpose To determine the efficacy and safety of different prophylactic systemic antibiotics in
adult and pediatric patients receiving chemotherapy or undergoing hematopoietic stem cell …

Prevention and Treatment of Cancer-Related Infections, Version 3.2024, NCCN Clinical Practice Guidelines in Oncology

LR Baden, S Swaminathan, NG Almyroudis… - Journal of the National …, 2024 - jnccn.org
There is an increased risk of infection in patients with cancer that results in higher morbidity
and mortality. Several risk factors can predispose these patients to infectious complications …