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Morpholine, piperazine, and piperidine derivatives as antidiabetic agents
D Zolotareva, A Zazybin, A Dauletbakov, Y Belyankova… - Molecules, 2024 - mdpi.com
Diabetes mellitus is a severe endocrine disease that affects more and more people every
year. Modern medical chemistry sets itself the task of finding effective and safe drugs against …
year. Modern medical chemistry sets itself the task of finding effective and safe drugs against …
A comprehensive review on the research progress of PTP1B inhibitors as antidiabetics
Diabetes mellitus (DM) is a serious global health concern affecting over 500 million people.
To put it simply, it is one of the most dangerous metabolic illnesses. Insulin resistance is the …
To put it simply, it is one of the most dangerous metabolic illnesses. Insulin resistance is the …
SAR and lead optimization of (Z)-5-(4-hydroxy-3-methoxybenzylidene)-3-(2-morpholinoacetyl) thiazolidine-2, 4-dione as a potential multi-target antidiabetic agent
In case of metabolic disorder like Diabetes mellitus (DM), a number of key enzymes are
abnormally expressed and hence they might be excellent targets for antidiabetic drug …
abnormally expressed and hence they might be excellent targets for antidiabetic drug …
Anti-diabetic Activity of Brucine in Streptozotocin-Induced Rats: In Silico, In Vitro, and In Vivo Studies
Diabetes mellitus (DM) is a complex and multiple group of disorders, and understanding the
molecular mechanisms is a key role in identifying various markers involved in the diagnosis …
molecular mechanisms is a key role in identifying various markers involved in the diagnosis …
[HTML][HTML] Anti-Inflammatory, Analgesic and Antioxidant Potential of New (2S,3S)-2-(4-isopropylbenzyl)-2-methyl-4-nitro-3-phenylbutanals and Their Corresponding …
In the current study, a series of new (2 S, 3 S)-2-(4-isopropylbenzyl)-2-methyl-4-nitro-3-
phenylbutanals (FM1-6) with their corresponding carboxylic acid analogues (FM7-12) has …
phenylbutanals (FM1-6) with their corresponding carboxylic acid analogues (FM7-12) has …
[PDF][PDF] Evaluation of the Antidiabetic Effects of Methanolic Extracts of Neem (Azadirachta indica) Seeds on the Streptozotocin-induced Wistar Rats.
Plants are among the most prominent candidates in herbal medicine. Vast research is being
performed for effective plants against diabetes. This experiment aimed to evaluate the …
performed for effective plants against diabetes. This experiment aimed to evaluate the …
New succinimide–thiazolidinedione hybrids as multitarget antidiabetic agents: design, synthesis, bioevaluation, and molecular modelling studies
Diabetes mellitus (DM) is a metabolic disorder majorly arising from the pathophysiology of
the pancreas manifested as a decline in the insulin production or the tissue's resistance to …
the pancreas manifested as a decline in the insulin production or the tissue's resistance to …
Novel hybrids of thiazolidinedione-1, 3, 4-oxadiazole derivatives: synthesis, molecular docking, MD simulations, ADMET study, in vitro, and in vivo anti-diabetic …
MG Srinivasa, JG Paithankar, SRS Birangal, A Pai… - RSC …, 2023 - pubs.rsc.org
As compared to standard medicinal compounds, hybrid molecules that contain multiple
biologically active functional groups have greater affinity and efficiency. Hence based on this …
biologically active functional groups have greater affinity and efficiency. Hence based on this …
[HTML][HTML] α-glucosidase, α-amylase and antioxidant evaluations of isolated bioactives from wild strawberry
MA Huneif, SM Alqahtani, A Abdulwahab… - Molecules, 2022 - mdpi.com
Diabetes mellitus is a metabolic disorder and is a global challenge to the current medicinal
chemists and pharmacologists. This research has been designed to isolate and evaluate …
chemists and pharmacologists. This research has been designed to isolate and evaluate …
Identification of isobenzofuranone derivatives as promising antidiabetic agents: Synthesis, in vitro and in vivo inhibition of α-glucosidase and α-amylase …
Diabetes mellitus, one of the major health challenges of the 21st century, is associated with
numerous biomedical complications including retinopathy, neuropathy, nephropathy …
numerous biomedical complications including retinopathy, neuropathy, nephropathy …