Glioblastoma (GBM) is the most common and malignant primary brain tumor in adults
associated with a poor survival. Current standard of care consists of surgical resection …

Glioblastoma is the most common primary brain tumor in adults with poor overall outcome
and 5-year survival of less than 5%. Treatment has not changed much in the last decade or …

Certain gliomas often harbor a mutation in the activity center of IDH1 (R132H), which leads
to the production of the oncometabolite 2-R-2-hydroxyglutarate (2-HG). In six model …

The incidence and mortality of hepatocellular carcinoma (HCC) are on a rise in the Western
countries including US, attributed mostly to late detection. Sorafenib has been the first-line …

Purpose: The goal of this study is to enhance the efficacy of imipridones, a novel class of
AKT/ERK inhibitors that displayed limited therapeutic efficacy against glioblastoma (GBM) …

The mesenchymal (MES) subtype of glioblastoma (GBM) stem cells (GSCs) represents a
subpopulation of cancer cells that are notorious for their highly aggressive nature and …

Background Dysregulation of the metabolome is a hallmark of primary brain malignancies.
In this work we examined whether metabolic reprogramming through a multi-targeting …

Rational therapeutic approaches based on synthetic lethality may improve cancer
management. On the basis of a high-throughput drug screen, we provide preclinical proof of …

Cortex lycii radicis is the dried root bark of Lycium chinense, a traditional Chinese herb used
in multiple ailments. The crude extract of Cortex lycii radicis has growth inhibition effect on …

Introduction: Novel approaches to treat malignant brain tumors are necessary since these
neoplasms still display an unfavorable prognosis. Areas covered: In this review, the authors …