Extensive map** of neuronal connections in the central nervous system requires high-
throughput µm-scale imaging of large volumes. In recent years, different approaches have …

Hippocampal synaptic plasticity is important for learning and memory formation.
Homeostatic synaptic plasticity is a specific form of synaptic plasticity that is induced upon …

The Human Brain Project (HBP) is a European flagship project with a 10-year horizon
aiming to understand the human brain and to translate neuroscience knowledge into …

The distinct organization of the brain's vascular network ensures that it is adequately
supplied with oxygen and nutrients. However, despite this fundamental role, a detailed …

Recently there has been an increasing trend to use deep learning frameworks for both 2D
consumer images and for 3D medical images. However, there has been little effort to use …

The cerebral vasculature has a unique role in providing a constant supply of oxygen and
nutrients to ensure normal brain functions. Blood vessels that feed the brain are far from …

Rationale: Classic histology is the gold standard for vascular network imaging and analysis.
The method however is laborious and prone to artefacts. Here, the suitability of …

Characterizing the cytoarchitecture of mammalian central nervous system on a brain-wide
scale is becoming a compelling need in neuroscience. For example, realistic modeling of …

While fluorescence microscopy has proven to be an exceedingly useful tool in bioscience, it
is difficult to offer simultaneous high resolution, fast speed, large volume, and good …

In recent years, three-dimensional mesoscopic imaging has gained significant importance in
life sciences for fundamental studies at the whole-organ level. In this manuscript, we present …