Exosomes─ nature's lipid nanoparticles, a rising star in drug delivery and diagnostics

R Tenchov, JM Sasso, X Wang, WS Liaw, CA Chen… - ACS …, 2022 - ACS Publications
Exosomes are a subgroup of nanosized extracellular vesicles enclosed by a lipid bilayer
membrane and secreted by most eukaryotic cells. They represent a route of intercellular …

Control of satellite cell function in muscle regeneration and its disruption in ageing

P Sousa-Victor, L García-Prat… - … Reviews Molecular Cell …, 2022 - nature.com
Skeletal muscle contains a designated population of adult stem cells, called satellite cells,
which are generally quiescent. In homeostasis, satellite cells proliferate only sporadically …

Non-coding RNAs in human health and disease: potential function as biomarkers and therapeutic targets

T Loganathan, GP Doss C - Functional & integrative genomics, 2023 - Springer
Human diseases have been a critical threat from the beginning of human history. Knowing
the origin, course of action and treatment of any disease state is essential. A microscopic …

miRNAs as biomarkers in disease: latest findings regarding their role in diagnosis and prognosis

CE Condrat, DC Thompson, MG Barbu, OL Bugnar… - Cells, 2020 - mdpi.com
MicroRNAs (miRNAs) represent a class of small, non-coding RNAs with the main roles of
regulating mRNA through its degradation and adjusting protein levels. In recent years …

miRTarBase 2020: updates to the experimentally validated microRNA–target interaction database

HY Huang, YCD Lin, J Li, KY Huang… - Nucleic acids …, 2020 - academic.oup.com
MicroRNAs (miRNAs) are small non-coding RNAs (typically consisting of 18–25
nucleotides) that negatively control expression of target genes at the post-transcriptional …

Therapeutics data commons: Machine learning datasets and tasks for drug discovery and development

K Huang, T Fu, W Gao, Y Zhao, Y Roohani… - arxiv preprint arxiv …, 2021 - arxiv.org
Therapeutics machine learning is an emerging field with incredible opportunities for
innovatiaon and impact. However, advancement in this field requires formulation of …

miRBase: from microRNA sequences to function

A Kozomara, M Birgaoanu… - Nucleic acids …, 2019 - academic.oup.com
Abstract miRBase catalogs, names and distributes microRNA gene sequences. The latest
release of miRBase (v22) contains microRNA sequences from 271 organisms: 38 589 …

The roles of microRNAs in epigenetic regulation

Q Yao, Y Chen, X Zhou - Current opinion in chemical biology, 2019 - Elsevier
MicroRNAs (miRNAs) are small noncoding RNAs, approximately 18–25 nucleotides in
length, now recognized as one of the major regulatory gene families in eukaryotes. Recent …

miRNAS in cardiovascular diseases: potential biomarkers, therapeutic targets and challenges

S Zhou, J **, J Wang, Z Zhang, JH Freedman… - Acta Pharmacologica …, 2018 - nature.com
Cardiovascular diseases (CVD) are the leading cause of morbidity and mortality in the
world. Although considerable progress has been made in the diagnosis, treatment and …

Making muscle: skeletal myogenesis in vivo and in vitro

J Chal, O Pourquié - Development, 2017 - journals.biologists.com
Skeletal muscle is the largest tissue in the body and loss of its function or its regenerative
properties results in debilitating musculoskeletal disorders. Understanding the mechanisms …