Much more than ever, nucleic acids are recognized as key building blocks in many of lifeʼs
processes, and the science of studying these molecular wonders at the single-molecule …

This tutorial review will introduce and explore the fundamental aspects of nanopore (bio)
sensing, fabrication, modification, and the emerging technologies and applications that both …

Nanopores bear great potential as sensors for single molecules, which are detected as
resistive pulses in a simple electrical measurement. The investigation of proteins requires …

Nanopores bear great potential as single-molecule tools for bioanalytical sensing and
sequencing, due to their exceptional sensing capabilities, high-throughput, and low cost …

In this paper we review the current status of high-performance computing applications in the
general area of drug discovery. We provide an introduction to the methodologies applied at …

We demonstrate the assembly of functional hybrid nanopores for single molecule sensing by
inserting DNA origami structures into solid-state nanopores. In our experiments, single …

The human proteome has millions of protein variants due to alternative RNA splicing and
post-translational modifications, and variants that are related to diseases are frequently …

Sequence identification of peptides and proteins is central to proteomics. Protein
sequencing is mainly conducted by insensitive mass spectroscopy because proteins cannot …

Since their introduction in 2001, solid-state nanopores have been increasingly exploited for
the detection and characterization of biomolecules ranging from single DNA strands to …

In the last two decades, new techniques that monitor ionic current modulations as single
molecules pass through a nanoscale pore have enabled numerous single-molecule studies …