Actin dynamics in cell motility, division, and phagocytosis is regulated by complex factors
with multiple feedback loops, often leading to emergent dynamic patterns in the form of …

Although directed migration of eukaryotic cells may have evolved to escape nutrient
depletion, it has been adopted for an extensive range of physiological events during …

During cell migration and polarization, numerous signal transduction and cytoskeletal
components self-organize to generate localized protrusions. Although biochemical and …

The network of proteins that orchestrate the distribution of cholesterol among cellular
organelles is not fully characterized. We previously proposed that oxysterol‐binding protein …

Endocytosis mediates the cellular uptake of micronutrients and the turnover of plasma
membrane proteins. Clathrin-mediated endocytosis is the major uptake pathway in resting …

Many cell-membrane-associated processes require transient spatiotemporal separation of
components on scales ranging from a couple of molecules to micrometers in size …

Cellular protrusions are typically considered as distinct structures associated with specific
regulators. However, we found that these regulators coordinately localize as propagating …

Methods to acutely manipulate protein interactions at the subcellular level are powerful tools
in cell biology. Several blue-light-dependent optical dimerization tools have been …

Dynamic processes in living cells are highly organized in space and time. Unraveling the
underlying molecular mechanisms of spatiotemporal pattern formation remains one of the …

B lymphocytes recognize bacterial or viral antigens via different classes of the B cell antigen
receptor (BCR). Protrusive structures termed microvilli cover lymphocyte surfaces, and are …