Tuberculosis (TB) was announced as a global emergency in 1993. There was an alarming
counter attack of TB worldwide. However, when it was known that TB can be cured …

The development of highly effective conjugate chemistry approaches is a way to improve the
quality of drugs and of medicines. The aim of this paper is to highlight and review such …

Page 1 WHO Module 4: Treatment Drug-susceptible tuberculosis treatment operational
handbook on tuberculosis World Health Organization Page 2 WHO operationa handbook …

Nanomedicine is a relatively new field that is rapidly evolving. Formulation of drugs on the
nanoscale imparts many physical and biological advantages. Such advantages can in turn …

Metalloenzymes are central to a wide range of essential biological activities, including
nucleic acid modification, protein degradation, and many others. The role of metalloenzymes …

The highly divergent ribosomes of human mitochondria (mitoribosomes) synthesize 13
essential proteins of oxidative phosphorylation complexes. We have determined the …

Antimicrobial resistance is one of the greatest challenges of the 21st century. Evaluation of
the public health burden of antimicrobial resistance, which is needed to drive policy …

The increasing prevalence of hospital and community-acquired infections caused by
multidrug-resistant (MDR) bacterial pathogens is limiting the options for effective antibiotic …

For the successful treatment of pulmonary tuberculosis, drugs need to penetrate complex
lung lesions and permeate the mycobacterial cell wall in order to reach their intracellular …

Background Treatment of multidrug resistant tuberculosis (MDR-TB) is lengthy, toxic,
expensive, and has generally poor outcomes. We undertook an individual patient data meta …