Microfluidic devices: a tool for nanoparticle synthesis and performance evaluation

S Gimondi, H Ferreira, RL Reis, NM Neves - ACS nano, 2023 - ACS Publications
The use of nanoparticles (NPs) in nanomedicine holds great promise for the treatment of
diseases for which conventional therapies present serious limitations. Additionally, NPs can …

The blood–brain barrier: composition, properties, and roles in brain health

B Lacoste, A Prat… - Cold Spring Harbor …, 2024 - cshperspectives.cshlp.org
Blood vessels are critical to deliver oxygen and nutrients to tissues and organs throughout
the body. The blood vessels that vascularize the central nervous system (CNS) possess …

Breaking the resolution limits of 3D bioprinting: future opportunities and present challenges

T Zandrini, S Florczak, R Levato, A Ovsianikov - Trends in biotechnology, 2023 - cell.com
Bioprinting aims to produce 3D structures from which embedded cells can receive
mechanical and chemical stimuli that influence their behavior, direct their organization and …

Standardizing designed and emergent quantitative features in microphysiological systems

DM Nahon, R Moerkens, H Aydogmus… - Nature biomedical …, 2024 - nature.com
Microphysiological systems (MPSs) are cellular models that replicate aspects of organ and
tissue functions in vitro. In contrast with conventional cell cultures, MPSs often provide …

Interstitial flow promotes the formation of functional microvascular networks in vitro through upregulation of matrix metalloproteinase‐2

S Zhang, Z Wan, G Pavlou, AX Zhong… - Advanced functional …, 2022 - Wiley Online Library
Self‐organized microvascular networks (MVNs) have become key to the development of
many microphysiological models. However, the self‐organizing nature of this process …

A predictive microfluidic model of human glioblastoma to assess trafficking of blood–brain barrier-penetrant nanoparticles

JP Straehla, C Hajal, HC Safford… - Proceedings of the …, 2022 - National Acad Sciences
The blood–brain barrier represents a significant challenge for the treatment of high-grade
gliomas, and our understanding of drug transport across this critical biointerface remains …

Three‐dimensional multicellular biomaterial platforms for biomedical application

J Hao, C Qin, C Wu - Interdisciplinary Materials, 2023 - Wiley Online Library
Abstract The three‐dimensional (3D) multicellular platforms prepared by cells or
biomaterials have been widely applied in biomedical fields for the regeneration of complex …

Meta-analysis of the make-up and properties of in vitro models of the healthy and diseased blood–brain barrier

JG Shamul, Z Wang, H Gong, W Ou, AM White… - Nature Biomedical …, 2024 - nature.com
In vitro models of the human blood–brain barrier (BBB) are increasingly used to develop
therapeutics that can cross the BBB for treating diseases of the central nervous system. Here …

Microfluidic trends in drug screening and drug delivery

J Feng, J Neuzil, A Manz, C Iliescu, P Neuzil - TrAC Trends in Analytical …, 2023 - Elsevier
The low probability of a drug candidate's clinical success, the time consumed and the high
cost of bringing a drug from concept to market emphasizes the need for new approaches to …

Development of a perfusable, hierarchical microvasculature-on-a-chip model

SW Chen, A Blazeski, S Zhang, SE Shelton… - Lab on a Chip, 2023 - pubs.rsc.org
Several methods have been developed for generating 3D, in vitro, organ-on-chip models of
human vasculature to study vascular function, transport, and tissue engineering. However …