Microfluidic devices: a tool for nanoparticle synthesis and performance evaluation
The use of nanoparticles (NPs) in nanomedicine holds great promise for the treatment of
diseases for which conventional therapies present serious limitations. Additionally, NPs can …
diseases for which conventional therapies present serious limitations. Additionally, NPs can …
The blood–brain barrier: composition, properties, and roles in brain health
Blood vessels are critical to deliver oxygen and nutrients to tissues and organs throughout
the body. The blood vessels that vascularize the central nervous system (CNS) possess …
the body. The blood vessels that vascularize the central nervous system (CNS) possess …
Breaking the resolution limits of 3D bioprinting: future opportunities and present challenges
Bioprinting aims to produce 3D structures from which embedded cells can receive
mechanical and chemical stimuli that influence their behavior, direct their organization and …
mechanical and chemical stimuli that influence their behavior, direct their organization and …
Standardizing designed and emergent quantitative features in microphysiological systems
DM Nahon, R Moerkens, H Aydogmus… - Nature biomedical …, 2024 - nature.com
Microphysiological systems (MPSs) are cellular models that replicate aspects of organ and
tissue functions in vitro. In contrast with conventional cell cultures, MPSs often provide …
tissue functions in vitro. In contrast with conventional cell cultures, MPSs often provide …
Interstitial flow promotes the formation of functional microvascular networks in vitro through upregulation of matrix metalloproteinase‐2
Self‐organized microvascular networks (MVNs) have become key to the development of
many microphysiological models. However, the self‐organizing nature of this process …
many microphysiological models. However, the self‐organizing nature of this process …
A predictive microfluidic model of human glioblastoma to assess trafficking of blood–brain barrier-penetrant nanoparticles
The blood–brain barrier represents a significant challenge for the treatment of high-grade
gliomas, and our understanding of drug transport across this critical biointerface remains …
gliomas, and our understanding of drug transport across this critical biointerface remains …
Three‐dimensional multicellular biomaterial platforms for biomedical application
J Hao, C Qin, C Wu - Interdisciplinary Materials, 2023 - Wiley Online Library
Abstract The three‐dimensional (3D) multicellular platforms prepared by cells or
biomaterials have been widely applied in biomedical fields for the regeneration of complex …
biomaterials have been widely applied in biomedical fields for the regeneration of complex …
Meta-analysis of the make-up and properties of in vitro models of the healthy and diseased blood–brain barrier
In vitro models of the human blood–brain barrier (BBB) are increasingly used to develop
therapeutics that can cross the BBB for treating diseases of the central nervous system. Here …
therapeutics that can cross the BBB for treating diseases of the central nervous system. Here …
Microfluidic trends in drug screening and drug delivery
The low probability of a drug candidate's clinical success, the time consumed and the high
cost of bringing a drug from concept to market emphasizes the need for new approaches to …
cost of bringing a drug from concept to market emphasizes the need for new approaches to …
Development of a perfusable, hierarchical microvasculature-on-a-chip model
Several methods have been developed for generating 3D, in vitro, organ-on-chip models of
human vasculature to study vascular function, transport, and tissue engineering. However …
human vasculature to study vascular function, transport, and tissue engineering. However …