Anticancer copper pyridine benzimidazole complexes: ROS generation, biomolecule interactions, and cytotoxicity

KE Prosser, SW Chang, F Saraci, PH Le… - Journal of inorganic …, 2017 - Elsevier
Abstract The Cu (II) complex CuCl 2 (pbzH), pbzH= 2-(2-pyridyl) benzimidazole, and
derivatives modified at the non-coordinated nitrogen of the benzimidazole fragment, have …

DFT, ADMET and Molecular Docking Investigations for the Antimicrobial Activity of 6, 6′-Diamino-1, 1′, 3, 3′-tetramethyl-5, 5′-(4-chlorobenzylidene) bis …

NT El-Shamy, AM Alkaoud, RK Hussein, MA Ibrahim… - Molecules, 2022 - mdpi.com
Heterocyclic compounds, including pyrimidine derivatives, exhibit a broad variety of
biological and pharmacological activities. In this paper, a previously synthesized novel …

Copper (II) complexes with mixed heterocycle ligands as promising antibacterial and antitumor species

AM Rostas, M Badea, LL Ruta, IC Farcasanu, C Maxim… - Molecules, 2020 - mdpi.com
Complexes with mixed ligands [Cu (NN) 2 (pmtp)](ClO4) 2 ((1) NN: 2, 2′-bipyridine;(2) L: 1,
10-phenanthroline and pmpt: 5-phenyl-7-methyl-1, 2, 4-triazolo [1, 5-a] pyrimidine) were …

Ternary copper complex of L-Glutamine and phenanthroline as counterions of cyclo-tetravanadate anion: Experimental–theoretical characterization and potential …

ND Corona-Motolinia, B Martinez-Valencia, L Noriega… - Metals, 2021 - mdpi.com
Over the last decade, therapeutic metallodrugs have become substantially effective in the
treatment of cancer. Thus, develo** new effective anticancer drugs is a significant …

Biological activity of triazolopyrimidine copper (II) complexes modulated by an auxiliary NN-chelating heterocycle ligands

LL Ruta, IC Farcasanu, M Bacalum, M Răileanu… - Molecules, 2021 - mdpi.com
Novel complexes of type [Cu (NN)(dmtp) 2 (OH2)](ClO4) 2· dmtp ((1) NN: 2, 2′-
bipyridine;(2) L: 1, 10-phenantroline and dmtp: 5, 7-dimethyl-1, 2, 4-triazolo [1, 5-a] …

Structural, optical and thermal analysis of creatininium borate–A new semiorganic nlo single crystal

S Sindhusha, CM Padma, B Gunasekaran… - Journal of Molecular …, 2020 - Elsevier
The main focus of this work is to synthesize creatininium borate (CRB) single crystal by
using slow evaporation technique and to analyse the physiochemical properties. The grown …

Synthesis, structural characterization, cytotoxic properties and DNA binding of a dinuclear copper (II) complex

BJML Ferreira, P Brandão, M Meireles, F Martel… - Journal of Inorganic …, 2016 - Elsevier
In this study a novel dinuclear copper (II) complex with adenine and phenanthroline has
been synthesized and its structure determined by single crystal X-ray diffraction. In the …

Synthesis, crystal structure, and computational methods of vanadium and copper compounds as potential drugs for cancer treatment

ND Corona-Motolinia, B Martínez-Valencia, L Noriega… - Molecules, 2020 - mdpi.com
Transition metal-based compounds have shown promising uses as therapeutic agents.
Among their unique characteristics, these compounds are suitable for interaction with …

Antiproliferative and antibacterial properties of biocompatible copper (II) complexes bearing chelating N, N-heterocycle ligands and potential mechanisms of action

R Olar, M Badea, M Bacalum, M Răileanu, LL Ruţă… - Biometals, 2021 - Springer
In an attempt to propose new applications for the biomedical field, complexes with mixed
ligands {[Cu (bpy) 2 (μ 2 OClO 3)] ClO 4} n (1) and [Cu (phen) 2 (OH 2)](ClO 4) 2 (2)(bpy: 2 …

Synthesis, DFT calculations, spectroscopy and in vitro antioxidant activity studies on 4-hydroxyphenyl substituted thiopyrimidine derivatives

E Akbas, S Ekin, E Ergan, Y Karakus - Journal of Molecular Structure, 2018 - Elsevier
Hydroxyphenyl substituted thiopyrimidine derivatives have been synthesized with the
starting compound 5-benzoyl-6-phenyl-4-(4-hydroxyphenyl)-1, 2, 3, 4-tetrahydro-2 …