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The role of metabolism in toxicity of polycyclic aromatic hydrocarbons and their non-genotoxic modes of action
J Vondráček, M Machala - Current Drug Metabolism, 2021 - benthamdirect.com
Polycyclic aromatic hydrocarbons (PAHs) represent a class of widely distributed
environmental pollutants that have been primarily studied as genotoxic compounds. Their …
environmental pollutants that have been primarily studied as genotoxic compounds. Their …
The shared pathoetiological effects of particulate air pollution and the social environment on fetal‐placental development
Exposure to particulate air pollution and socioeconomic risk factors are shown to be
independently associated with adverse pregnancy outcomes; however, their confounding …
independently associated with adverse pregnancy outcomes; however, their confounding …
In vitro profiling of toxic effects of environmental polycyclic aromatic hydrocarbons on nuclear receptor signaling, disruption of endogenous metabolism and induction …
P Šimečková, K Pěnčíková, O Kováč, J Slavík… - Science of The Total …, 2022 - Elsevier
Polycyclic aromatic hydrocarbons (PAHs) may interact with multiple intracellular receptors
and related signaling pathways. We comprehensively evaluated the toxicity profiles of six …
and related signaling pathways. We comprehensively evaluated the toxicity profiles of six …
Effect of PM2. 5 environmental pollution on rat lung
B Yang, J Guo, C **ao - Environmental Science and Pollution Research, 2018 - Springer
Particulate matter smaller than 2.5 μm (PM2. 5) is a continuing challenge to pulmonary
health. Here, we investigated the mechanisms involved in PM2. 5 exposure-induced acute …
health. Here, we investigated the mechanisms involved in PM2. 5 exposure-induced acute …
[HTML][HTML] Emissions and atmospheric processes influence the chemical composition and toxicological properties of urban air particulate matter in Nan**g, China
TJ Rönkkö, PI Jalava, MS Happo, S Kasurinen… - Science of the Total …, 2018 - Elsevier
Ambient inhalable particulate matter (PM) is a serious health concern worldwide, but
especially so in China where high PM concentrations affect huge populations. Atmospheric …
especially so in China where high PM concentrations affect huge populations. Atmospheric …
Polycyclic aromatic hydrocarbons (PAHs) present in ambient urban dust drive proinflammatory T cell and dendritic cell responses via the aryl hydrocarbon receptor …
CA O'Driscoll, ME Gallo, EJ Hoffmann, JH Fechner… - PLoS …, 2018 - journals.plos.org
Atmospheric particulate matter (PM) is a complex component of air pollution that is a
composed of inorganic and organic constituents. The chemically-extracted organic fraction …
composed of inorganic and organic constituents. The chemically-extracted organic fraction …
Crosstalk between AhR and wnt/β-catenin signal pathways in the cardiac developmental toxicity of PM2. 5 in zebrafish embryos
H Zhang, Y Yao, Y Chen, C Yue, J Chen, J Tong… - Toxicology, 2016 - Elsevier
Recent studies have shown an association between congenital heart defects and air fine
particle matter (PM2. 5), but the molecular mechanisms remain elusive. It is well known that …
particle matter (PM2. 5), but the molecular mechanisms remain elusive. It is well known that …
Combined exposure to nano-silica and lead induced potentiation of oxidative stress and DNA damage in human lung epithelial cells
Growing evidence has confirmed that exposure to ambient particulate matters (PM) is
associated with increased morbidity and mortality of cardiovascular and pulmonary …
associated with increased morbidity and mortality of cardiovascular and pulmonary …
The aryl hydrocarbon receptor as an immune-modulator of atmospheric particulate matter-mediated autoimmunity
CA O'Driscoll, JD Mezrich - Frontiers in immunology, 2018 - frontiersin.org
This review examines the current literature on the effects of atmospheric particulate matter
(PM) on autoimmune disease and proposes a new role for the aryl hydrocarbon receptor …
(PM) on autoimmune disease and proposes a new role for the aryl hydrocarbon receptor …
Formation of Developmentally Toxic Phenanthrene Metabolite Mixtures by Mycobacterium sp. ELW1
JE Schrlau, AL Kramer, A Chlebowski… - … science & technology, 2017 - ACS Publications
Mycobacterium sp. ELW1 co-metabolically degraded up to 1.8 μmol of phenanthrene (PHE)
in∼ 48 h, and hydroxyphenanthrene (OHPHE) metabolites, including 1 …
in∼ 48 h, and hydroxyphenanthrene (OHPHE) metabolites, including 1 …