Marek's disease vaccines: a solution for today but a worry for tomorrow?

IM Gimeno - Vaccine, 2008 - Elsevier
Marek's disease (MD) is a lymphoproliferative disease of chickens that, in the absence of
control measures, is capable of causing devastating losses in commercial poultry flocks. MD …

Release of HSV-1 cell-free virions: Mechanisms, regulation, and likely role in human-human transmission

SA Rice - Viruses, 2021 - mdpi.com
Herpes simplex virus type 1, or HSV-1, is a widespread human pathogen that replicates in
epithelial cells of the body surface and then establishes latent infection in peripheral …

Evolution and diversity in human herpes simplex virus genomes

ML Szpara, D Gatherer, A Ochoa, B Greenbaum… - Journal of …, 2014 - journals.asm.org
ABSTRACT Herpes simplex virus 1 (HSV-1) causes a chronic, lifelong infection in> 60% of
adults. Multiple recent vaccine trials have failed, with viral diversity likely contributing to …

Sequence variability in clinical and laboratory isolates of herpes simplex virus 1 reveals new mutations

ML Szpara, L Parsons, LW Enquist - Journal of virology, 2010 - journals.asm.org
ABSTRACT Herpes simplex virus 1 (HSV-1) is a well-adapted human pathogen that can
invade the peripheral nervous system and persist there as a lifelong latent infection. Despite …

Herpesvirus telomeric repeats facilitate genomic integration into host telomeres and mobilization of viral DNA during reactivation

BB Kaufer, KW Jarosinski, N Osterrieder - Journal of Experimental …, 2011 - rupress.org
Some herpesviruses, particularly lymphotropic viruses such as Marek's disease virus (MDV)
and human herpesvirus 6 (HHV-6), integrate their DNA into host chromosomes. MDV and …

Marek's Disease Viral Interleukin-8 Promotes Lymphoma Formation through Targeted Recruitment of B Cells and CD4+ CD25+ T Cells

AT Engel, RK Selvaraj, JP Kamil, N Osterrieder… - Journal of …, 2012 - journals.asm.org
Marek's disease virus (MDV) is a cell-associated and highly oncogenic alphaherpesvirus
that infects chickens. During lytic and latent MDV infection, a CXC chemokine termed viral …

Role of the arginine cluster in the disordered domain of herpes simplex virus 1 UL34 for the recruitment of ESCRT-III for viral primary envelopment

J Arii, K Takeshima, Y Maruzuru, N Koyanagi… - Journal of …, 2022 - journals.asm.org
During the nuclear export of nascent nucleocapsids of herpesviruses, the nucleocapsids
bud through the inner nuclear membrane (INM) by acquiring the INM as a primary envelope …

[HTML][HTML] Virus and host genomic, molecular, and cellular interactions during Marek's disease pathogenesis and oncogenesis

MC McPherson, ME Delany - Poultry science, 2016 - Elsevier
ABSTRACT Marek's Disease Virus (MDV) is a chicken alphaherpesvirus that causes
paralysis, chronic wasting, blindness, and fatal lymphoma development in infected …

[HTML][HTML] Enhancement of HSV-1 cell-free virion release by the envelope protein gC

TC Frost, M Salnikov, SA Rice - Virology, 2024 - Elsevier
Glycoprotein C (gC), one of∼ 12 HSV-1 envelope glycoproteins, carries out several
important functions during infection, including the enhancement of virion attachment by …

Attenuation of a very virulent Marek's disease herpesvirus (MDV) by codon pair bias deoptimization

K Eschke, J Trimpert, N Osterrieder, D Kunec - PLoS pathogens, 2018 - journals.plos.org
Codon pair bias deoptimization (CPBD) has enabled highly efficient and rapid attenuation of
RNA viruses. The technique relies on recoding of viral genes by increasing the number of …