Propofol (2, 6-diisopropylphenol) is a potent intravenous hypnotic agent which is widely
used for the induction and maintenance of anesthesia and for sedation in the intensive care …

Propofol infusion syndrome (PRIS) is a rare and often fatal syndrome described in critically
ill children undergoing long-term propofol infusion at high doses. Recently several cases …

The American College of Critical Care Medicine (ACCM), which honors individuals for their
achievements and contributions to multidisciplinary critical care medicine, is the consultative …

Traumatic brain injury (TBI) is a common disorder with high morbidity and mortality,
accounting for one in every three deaths due to injury. Older adults are especially …

Objectives: To summarize randomized controlled trials on the effects of sedative agents on
neurologic outcome, mortality, intracranial pressure, cerebral perfusion pressure, and …

Abstract THERE IS NO question that substantial progress has been made over the last 30
years, since the pioneering multinational studies of Jennett and colleagues, in our …

The purpose of this study was to determine if the relationship between abnormalities in
glucose, lactate, and oxygen metabolism were predictive of neurologic outcome after …

Patients who are critically ill and on mechanical ventilation frequently require sedation and
analgesic therapy to optimize patient comfort, facilitate patient-ventilator synchrony, and …

Propofol (Diprivan® 1) is a phenolic derivative with sedative and hypnotic properties but is
unrelated to other sedative/hypnotic agents. Formulated as an oil-in-water emulsion for …

Objective: To determine the prevalence, time course, clinical characteristics, and effect of
adrenal insufficiency (AI) after traumatic brain injury (TBI). Design: Prospective intensive …