Critical care, like many healthcare areas, is under a dual assault from significantly
increasing demographic and economic pressures. Intensive care unit (ICU) patients are …

The control of diabetes is an interdisciplinary endeavor, which includes a significant
biomedical engineering component, with traditions of success beginning in the early 1960s …

This book comprehensively addresses the physics and engineering aspects of human
physiology by using and building on first-year college physics and mathematics. Topics …

Assessment of insulin secretion in humans under physiological conditions has been a
challenge because of its complex interplay with insulin action and hepatic insulin extraction …

Background We consider the problem of parameter estimation (model calibration) in
nonlinear dynamic models of biological systems. Due to the frequent ill-conditioning and …

In this tutorial paper we first present some foundational results regarding the theory of
positive systems. In particular, we present fundamental results regarding stability, positive …

Known as the bible of biomedical engineering, The Biomedical Engineering Handbook,
Fourth Edition, sets the standard against which all other references of this nature are …

Introduction to Modeling in Physiology and Medicine, Second Edition, develops a clear
understanding of the fundamental principles of good modeling methodology. Sections show …

This interdisciplinary guide explores various types of modeling methods available for
dynamical systems. It begins with the general concepts, representations, and philosophy of …

Background: Regulation of plasma glucose concentration for type 1 diabetic patients is
challenging, and exercise is an added complication. From a metabolic prospective, the …