Post-myocardial infarction fibrosis: Pathophysiology, examination, and intervention

X Yin, X Yin, X Pan, J Zhang, X Fan, J Li… - Frontiers in …, 2023 - frontiersin.org
Cardiac fibrosis plays an indispensable role in cardiac tissue homeostasis and repair after
myocardial infarction (MI). The cardiac fibroblast-to-myofibroblast differentiation and …

Radiotracers for Imaging of Inflammatory Biomarkers TSPO and COX-2 in the Brain and in the Periphery

BC Uzuegbunam, C Rummel, D Librizzi… - International Journal of …, 2023 - mdpi.com
Inflammation involves the activation of innate immune cells and is believed to play an
important role in the development and progression of both infectious and non-infectious …

Systems immunology-based drug repurposing framework to target inflammation in atherosclerosis

L Amadori, C Calcagno, DM Fernandez… - Nature cardiovascular …, 2023 - nature.com
The development of new immunotherapies to treat the inflammatory mechanisms that
sustain atherosclerotic cardiovascular disease (ASCVD) is urgently needed. Herein, we …

Recent advances in cardiovascular diseases research using animal models and PET radioisotope tracers

W Wargocka-Matuszewska, W Uhrynowski… - International Journal of …, 2022 - mdpi.com
Cardiovascular diseases (CVD) is a collective term describing a range of conditions that
affect the heart and blood vessels. Due to the varied nature of the disorders, distinguishing …

Imaging inflammation past, present, and future: focus on cardioimmunology

JT Thackeray, KJ Lavine, Y Liu - Journal of Nuclear Medicine, 2023 - Soc Nuclear Med
Growing evidence implicates the immune system as a critical mediator of cardiovascular
disease progression and a viable therapeutic target. Increased inflammatory cell activity is …

Uncovering atherosclerotic cardiovascular disease by PET imaging

A Maier, AJP Teunissen, SA Nauta, E Lutgens… - Nature Reviews …, 2024 - nature.com
Assessing atherosclerosis severity is essential for precise patient stratification. Specifically,
there is a need to identify patients with residual inflammation because these patients remain …

Highlighting fibroblasts activation in fibrosis: the state-of-the-art fibroblast activation protein inhibitor PET imaging in cardiovascular diseases

Y Cui, Y Wang, S Wang, B Du, X Li, Y Li - Journal of Clinical Medicine, 2023 - mdpi.com
Fibrosis is a common healing process that occurs during stress and injury in cardiovascular
diseases. The evolution of fibrosis is associated with cardiovascular disease states and …

Gallium-68 labelled radiopharmaceuticals for imaging inflammatory disorders

M Vorster - Seminars in Nuclear Medicine, 2023 - Elsevier
Inflammation is an important component of several chronic and debilitating diseases that
result in significant morbidity and mortality. This is best evidenced within the cardiovascular …

Imaging carotid plaque inflammation using positron emission tomography: emerging role in clinical stroke care, research applications, and future directions

JJ McCabe, NR Evans, S Gorey, S Bhakta, JHF Rudd… - Cells, 2023 - mdpi.com
Atherosclerosis is a chronic systemic inflammatory condition of the vasculature and a
leading cause of stroke. Luminal stenosis severity is an important factor in determining …

[HTML][HTML] Novel tracers to assess myocardial inflammation with radionuclide imaging

YA Lucinian, P Martineau, G Abikhzer, F Harel… - Journal of Nuclear …, 2024 - Elsevier
Myocardial inflammation plays a central role in the pathophysiology of various cardiac
diseases. While FDG-PET is currently the primary method for molecular imaging of …