Our knowledge about the genetics of myelodysplastic syndromes (MDS) and related
myeloid disorders has been dramatically improved during the past decade, in which …

Array manufacturers originally designed single nucleotide polymorphism (SNP) arrays to
genotype human DNA at thousands of SNPs across the genome simultaneously. In the …

Clonal expansion in aged normal tissues has been implicated in the development of cancer.
However, the chronology and risk dependence of the expansion are poorly understood …

Successful treatment of many patients with advanced cancer using antibodies against
programmed cell death 1 (PD-1; also known as PDCD1) and its ligand (PD-L1; also known …

Adult T cell leukemia/lymphoma (ATL) is a peripheral T cell neoplasm of largely unknown
genetic basis, associated with human T cell leukemia virus type-1 (HTLV-1) infection. Here …

Grade II and III gliomas are generally slowly progressing brain cancers, many of which
eventually transform into more aggressive tumors. Despite recent findings of frequent …

To elucidate differential roles of mutations in myelodysplastic syndromes (MDS), we
investigated clonal dynamics using whole-exome and/or targeted sequencing of 699 …

Background In patients with acquired aplastic anemia, destruction of hematopoietic cells by
the immune system leads to pancytopenia. Patients have a response to immunosuppressive …

Upper urinary tract urothelial carcinoma (UTUC) is one of the common urothelial cancers. Its
molecular pathogenesis, however, is poorly understood, with no useful biomarkers available …

Most cases of adult myeloid neoplasms are routinely assumed to be sporadic. Here, we
describe an adult familial acute myeloid leukemia (AML) syndrome caused by germline …