[HTML][HTML] Bioinspired silk fibroin materials: From silk building blocks extraction and reconstruction to advanced biomedical applications

X Yao, S Zou, S Fan, Q Niu, Y Zhang - Materials Today Bio, 2022 - Elsevier
Silk fibroin has become a promising biomaterial owing to its remarkable mechanical
property, biocompatibility, biodegradability, and sufficient supply. However, it is difficult to …

Opportunities and challenges in cardiac tissue engineering from an analysis of two decades of advances

RZ Zhuang, R Lock, B Liu… - Nature Biomedical …, 2022 - nature.com
Engineered human cardiac tissues facilitate progress in regenerative medicine, disease
modelling and drug development. In this Perspective, we reflect on the most notable …

Biomaterials-mediated CRISPR/Cas9 delivery: recent challenges and opportunities in gene therapy

AK Dubey, E Mostafavi - Frontiers in Chemistry, 2023 - frontiersin.org
The use of biomaterials in delivering CRISPR/Cas9 for gene therapy in infectious diseases
holds tremendous potential. This innovative approach combines the advantages of …

Design of recombinant spider silk proteins for cell type specific binding

VT Trossmann, T Scheibel - Advanced Healthcare Materials, 2023 - Wiley Online Library
Cytophilic (cell‐adhesive) materials are very important for tissue engineering and
regenerative medicine. However, for engineering hierarchically organized tissue structures …

3D‐Printed and Recombinant Spider Silk Particle Reinforced Collagen Composite Scaffolds for Soft Tissue Engineering

KS Koeck, VT Trossmann… - Advanced Functional …, 2024 - Wiley Online Library
Collagen is one main component of the extracellular matrix (ECM) in natural tissues and is,
therefore, well suited as a biomaterial for tissue engineering. In this study, a method is …

Bioengineering of spider silks for the production of biomedical materials

DMC Bittencourt, P Oliveira… - … in Bioengineering and …, 2022 - frontiersin.org
Spider silks are well known for their extraordinary mechanical properties. This characteristic
is a result of the interplay of composition, structure and self-assembly of spider silk proteins …

Structure–Property relationship based on the amino acid composition of recombinant spider silk proteins for potential biomedical applications

S Lentz, VT Trossmann, CB Borkner… - … Applied Materials & …, 2022 - ACS Publications
Improving biomaterials by engineering application-specific and adjustable properties is of
increasing interest. Most of the commonly available materials fulfill the mechanical and …

Factors influencing properties of spider silk coatings and their interactions within a biological environment

VT Trossmann, S Lentz, T Scheibel - Journal of Functional Biomaterials, 2023 - mdpi.com
Biomaterials are an indispensable part of biomedical research. However, although many
materials display suitable application-specific properties, they provide only poor …

Selective topography directed cell adhesion on spider silk surfaces

S Lentz, VT Trossmann… - Advanced Materials …, 2023 - Wiley Online Library
For tissue engineering applications, guided cell interaction with a biomaterial surface is one
essential feature since, in natural tissue, cells constantly interact with their extracellular …

Aptamer‐modified Nanohydrogel microarrays for bioselective cancer cell immobilization

Z Lamberger, H Bargel… - Advanced Functional …, 2022 - Wiley Online Library
Photolithography combined with surface nucleated protein self‐assembly of azido‐modified
spider silk proteins is used to create an arbitrarily shaped, inherently cell repellent …