The rising incidence of type 2 diabetes mellitus (T2DM) is a major public health concern,
and novel therapeutic strategies to prevent T2DM are urgently needed worldwide. Aging is …

Abstract Sirtuin 2 (SIRT2) is an NAD+-dependent deacetylase that was under studied
compared to other sirtuin family members. SIRT2 is the only sirtuin protein which is …

Protein lysine acetylation is an important posttranslational modification that regulates
numerous biological processes. Targeting lysine acetylation regulatory factors, such as …

Diabetes is the most common metabolic disorder, with an extremely serious effect on health
systems worldwide. It has become a severe, chronic, non-communicable disease after …

Accumulating evidence has indicated that sirtuins are key components of diverse
physiological processes, including metabolism and aging. Sirtuins confer protection from a …

The key role of mitochondria in oxidative metabolism and redox homeostasis explains the
link between mitochondrial dysfunction and the development of metabolic disorders …

Aging leads to and is associated with aberrant function of multiple signaling pathways and a
host of factors that maintain cellular health. Under normal conditions, the prolongevity …

Nonalcoholic fatty liver disease (NAFLD) is characterized by hepatic steatosis, insulin
resistance, mitochondrial dysfunction, inflammation, and oxidative stress. As a group of …

Background and Aims Sirtuin 2 (SIRT2), an NAD+‐dependent deacetylase, is involved in
various cellular processes regulating metabolic homeostasis and inflammatory responses; …

Transforming growth factor-β (TGF-β) is the primary factor that drives fibrosis in most, if not
all, forms of chronic kidney disease. In kidneys that are obstructed, specific deletion of Sirt2 …