Ischemia-triggered glutamate excitotoxicity from the perspective of glial cells

D Belov Kirdajova, J Kriska, J Tureckova… - Frontiers in cellular …, 2020 - frontiersin.org
A plethora of neurological disorders shares a final common deadly pathway known as
excitotoxicity. Among these disorders, ischemic injury is a prominent cause of death and …

Understanding the NG2 glial scar after spinal cord injury

AR Hackett, JK Lee - Frontiers in neurology, 2016 - frontiersin.org
NG2 cells, also known as oligodendrocyte progenitor cells, are located throughout the
central nervous system and serve as a pool of progenitors to differentiate into …

The increased activity of TRPV4 channel in the astrocytes of the adult rat hippocampus after cerebral hypoxia/ischemia

O Butenko, D Dzamba, J Benesova, P Honsa… - PloS one, 2012 - journals.plos.org
The polymodal transient receptor potential vanilloid 4 (TRPV4) channel, a member of the
TRP channel family, is a calcium-permeable cationic channel that is gated by various stimuli …

Heterogeneity of astrocytes: from development to injury–single cell gene expression

V Rusnakova, P Honsa, D Dzamba, A Ståhlberg… - PLoS …, 2013 - journals.plos.org
Astrocytes perform control and regulatory functions in the central nervous system;
heterogeneity among them is still a matter of debate due to limited knowledge of their gene …

Astrocyte‐like subpopulation of NG2 glia in the adult mouse cortex exhibits characteristics of neural progenitor cells

L Janeckova, T Knotek, J Kriska, Z Hermanova… - Glia, 2024 - Wiley Online Library
Glial cells expressing neuron‐glial antigen 2 (NG2), also known as oligodendrocyte
progenitor cells (OPCs), play a critical role in maintaining brain health. However, their ability …

NMDA receptors in glial cells: pending questions

D Dzamba, P Honsa… - Current …, 2013 - ingentaconnect.com
Glutamate receptors of the N-methyl-D-aspartate (NMDA) type are involved in many
cognitive processes, including behavior, learning and synaptic plasticity. For a long time …

Wnt/β-Catenin signaling promotes differentiation of ischemia-activated adult neural stem/progenitor cells to neuronal precursors

J Kriska, L Janeckova, D Kirdajova, P Honsa… - Frontiers in …, 2021 - frontiersin.org
Modulating endogenous regenerative processes may represent a suitable treatment for
central nervous system (CNS) injuries, such as stroke or trauma. Neural stem/progenitor …

Ionic transporter activity in astrocytes, microglia, and oligodendrocytes during brain ischemia

L Annunziato, F Boscia… - Journal of Cerebral Blood …, 2013 - journals.sagepub.com
Glial cells constitute a large percentage of cells in the nervous system. During recent years,
a large number of studies have critically attributed to glia a new role which no longer reflects …

Transient astrocyte‐like NG2 glia subpopulation emerges solely following permanent brain ischemia

D Kirdajova, L Valihrach, M Valny, J Kriska… - Glia, 2021 - Wiley Online Library
abstract NG2 glia display wide proliferation and differentiation potential under physiological
and pathological conditions. Here, we examined these two features following different types …

NG2/CSPG4 and progranulin in the posttraumatic glial scar

MKE Schäfer, I Tegeder - Matrix biology, 2018 - Elsevier
Traumatic injury of the central nervous system is one of the leading causes of death and
disability in young adults. Failure of regeneration is caused by autonomous neuronal …