Sustained smouldering, or low-grade activation, of myeloid cells is a common hallmark of
several chronic neurological diseases, including multiple sclerosis. Distinct metabolic and …

Many machine learning applications in bioinformatics currently rely on matching gene
identities when analyzing input gene signatures and fail to take advantage of preexisting …

Complex multicellularity has emerged independently across a few eukaryotic lineages and
is often associated with the rise of elaborate, tightly coordinated developmental processes …

Genetic studies have identified≥ 240 loci associated with the risk of type 2 diabetes (T2D),
yet most of these loci lie in non-coding regions, masking the underlying molecular …

Zika virus (ZIKV) can infect human develo** brain (HDB) progenitors resulting in epidemic
microcephaly, whereas analogous cellular tropism offers treatment potential for the adult …

Ovarian cancer is one of the most prevalent gynaecological malignancies. The rapid
development of single-cell RNA sequencing (scRNA-seq) has allowed scientists to use this …

Aims Cardiac involvement is common in patients hospitalized with COVID-19 and correlates
with an adverse disease trajectory. While cardiac injury has been attributed to direct viral …

Abstract Phased, small interfering RNAs (PhasiRNAs) play a crucial role in supporting male
fertility in grasses. Earlier work in maize (Zea mays) and rice (Oryza sativa)—and …

Understanding the complex biological process of aging is of great value, especially as it can
help develop therapeutics to prolong healthy life. Predicting biological age from gene …

The transition from bulk to single-cell analyses refocused the computational challenges for
high-throughput sequencing data-processing. The core of single-cell pipelines is partitioning …