Cancer is driven by incremental changes that accumulate, eventually leading to oncogenic
transformation. Although genetic alterations dominate the way cancer biologists think about …

To maintain its high energy demand the heart is equipped with a highly complex and
efficient enzymatic machinery that orchestrates ATP production using multiple energy …

Ever since the brain was identified as an insulin-sensitive organ, evidence has rapidly
accumulated that insulin action in the brain produces multiple behavioral and metabolic …

Obesity is a risk factor for cancer development and is associated with poor prognosis in
multiple tumor types. The positive energy balance linked with obesity induces a variety of …

Insulin resistance is a major underlying mechanism for the “metabolic syndrome”, which is
also known as insulin resistance syndrome. Metabolic syndrome is increasing at an …

Metabolic syndrome (MS) is a collection of cardiometabolic risk factors that includes obesity,
insulin resistance, hypertension, and dyslipidemia. Although there has been significant …

Insulin resistance is common in individuals with obesity or type 2 diabetes (T2D), in which
circulating insulin levels are frequently increased. Recent epidemiological and clinical …

Tumor necrosis factor-α (TNF-α) is an important mediator of insulin resistance in obesity and
diabetes through its ability to decrease the tyrosine kinase activity of the insulin receptor (IR) …

Obesity is highly associated with insulin resistance and is the biggest risk factor for non-
insulin-dependent diabetes mellitus,,. The molecular basis of this common syndrome …

Protein tyrosine phosphatase–1B (PTP-1B) has been implicated in the negative regulation
of insulin signaling. Disruption of the mouse homolog of the gene encoding PTP-1B yielded …