MRSA lineage USA300 isolated from bloodstream infections exhibit altered virulence regulation

S Dyzenhaus, MJ Sullivan, B Alburquerque, D Boff… - Cell host & …, 2023 - cell.com
The epidemic community-associated methicillin-resistant Staphylococcus aureus (CA-
MRSA) USA300 lineage has recently become a leading cause of hospital-associated …

PcdA promotes orthogonal division plane selection in Staphylococcus aureus

F Ramos-León, BR Anjuwon-Foster… - Nature …, 2024 - nature.com
The bacterial pathogen, Staphylococcus aureus, grows by dividing in two alternating
orthogonal planes. How these cell division planes are positioned correctly is not known …

Efflux pump gene amplifications bypass necessity of multiple target mutations for resistance against dual-targeting antibiotic

KPT Silva, G Sundar, A Khare - Nature Communications, 2023 - nature.com
Antibiotics that have multiple cellular targets theoretically reduce the frequency of resistance
evolution, but adaptive trajectories and resistance mechanisms against such antibiotics are …

Staphylococcus aureus adapts to exploit collagen-derived proline during chronic infection

A Urso, IR Monk, YT Cheng, C Predella… - Nature …, 2024 - nature.com
Staphylococcus aureus is a pulmonary pathogen associated with substantial human
morbidity and mortality. As vaccines targeting virulence determinants have failed to be …

SarS is a repressor of Staphylococcus aureus bicomponent pore-forming leukocidins

EE Anderson, S Dyzenhaus, JK Ilmain… - Infection and …, 2023 - journals.asm.org
Staphylococcus aureus is a successful pathogen that produces a wide range of virulence
factors that it uses to subvert and suppress the immune system. These include the …

Recent Advances in Genetic Tools for Acinetobacter baumannii

EME Sykes, S Deo, A Kumar - Frontiers in Genetics, 2020 - frontiersin.org
Acinetobacter baumannii is classified as a top priority pathogen by the World Health
Organization (WHO) because of its widespread resistance to all classes of antibiotics. This …

Strategies for develo** CRISPR‐based gene editing methods in bacteria

Z Wu, Y Wang, Y Zhang, W Chen, Y Wang… - Small Methods, 2020 - Wiley Online Library
Gene editing is a fundamental technique for the identification of the linkages from genetic
determinants to significant biological phenotypes, and the engineering of industrial strains to …

Expanding the genetic toolbox for the obligate human pathogen Streptococcus pyogenes

N Lautenschläger, K Schmidt, C Schiffer… - … in Bioengineering and …, 2024 - frontiersin.org
Genetic tools form the basis for the study of molecular mechanisms. Despite many recent
advances in the field of genetic engineering in bacteria, genetic toolsets remain scarce for …

High‐throughput transposon sequencing highlights the cell wall as an important barrier for osmotic stress in methicillin resistant Staphylococcus aureus and …

CF Schuster, DM Wiedemann… - Molecular …, 2020 - Wiley Online Library
Staphylococcus aureus is an opportunistic pathogen that can cause soft tissue infections but
is also a frequent cause of foodborne illnesses. One contributing factor for this food …

The major autolysin Atl regulates the virulence of Staphylococcus aureus by controlling the sorting of LukAB

X Zheng, SX Ma, A St. John, VJ Torres - Infection and Immunity, 2022 - journals.asm.org
Infections caused by the Gram-positive bacterium Staphylococcus aureus remain a
significant health threat globally. The production of bicomponent pore-forming leukocidins …