Covering: 2013 to June 2018 Heterologous expression of natural product biosynthetic
pathways is of increasing interest in microbial biotechnology, drug discovery and …

Microbial natural products are a tremendous source of new bioactive chemical entities for
drug discovery. Next generation sequencing has revealed an unprecedented genomic …

Streptomyces has the largest repertoire of natural product biosynthetic gene clusters
(BGCs), yet develo** a universal engineering strategy for each Streptomyces species is …

Actinomycetes are historically important sources for secondary metabolites (SMs) with
applications in human medicine, animal health, and plant crop protection. It is now clear that …

Peptidic natural products (PNPs) are widely used compounds that include many antibiotics
and a variety of other bioactive peptides. Although recent breakthroughs in PNP discovery …

Actinomycetes have been proven to be an excellent source of secondary metabolites for
more than half a century. Exhibiting various bioactivities, they provide valuable approved …

An important unresolved issue in microbial secondary metabolite production is the
abundance of biosynthetic gene clusters that are not expressed under typical laboratory …

Actinomycetes continue to be important sources for the discovery of secondary metabolites
for applications in human medicine, animal health, and crop protection. With the maturation …

Centralized facilities for genetic engineering, or “biofoundries”, offer the potential to design
organisms to address emerging needs in medicine, agriculture, industry, and defense. The …

There is considerable interest in mining organisms for new natural products (NPs) and in
improving methods to overproduce valuable NPs. Because of the rapid development of tools …