Crohn's disease
Crohn's disease is an inflammatory bowel disease that is characterized by chronic
inflammation of any part of the gastrointestinal tract, has a progressive and destructive …
inflammation of any part of the gastrointestinal tract, has a progressive and destructive …
The multifaceted nature of IL-10: regulation, role in immunological homeostasis and its relevance to cancer, COVID-19 and post-COVID conditions
Interleukin-10 (IL-10) is a pleiotropic cytokine that has a fundamental role in modulating
inflammation and in maintaining cell homeostasis. It primarily acts as an anti-inflammatory …
inflammation and in maintaining cell homeostasis. It primarily acts as an anti-inflammatory …
Intestinal epithelial glycosylation in homeostasis and gut microbiota interactions in IBD
Inflammatory bowel disease (IBD) affects 6.8 million people globally. A variety of factors
have been implicated in IBD pathogenesis, including host genetics, immune dysregulation …
have been implicated in IBD pathogenesis, including host genetics, immune dysregulation …
Inflammatory bowel disease: a review of pre-clinical murine models of human disease
Crohn's disease (CD) and ulcerative colitis (UC) are both highly inflammatory diseases of
the gastrointestinal tract, collectively known as inflammatory bowel disease (IBD). Although …
the gastrointestinal tract, collectively known as inflammatory bowel disease (IBD). Although …
Regulatory T cells: the many faces of Foxp3
Regulatory T (Treg) cells expressing the transcription factor forkhead box P3 (Foxp3) play a
requisite role in the maintenance of immunological homeostasis and prevention of …
requisite role in the maintenance of immunological homeostasis and prevention of …
Genetic and epigenetic etiology of inflammatory bowel disease: An update
Inflammatory bowel disease (IBD) is a chronic disease with periods of exacerbation and
remission of the disease. The etiology of IBD is not fully understood. Many studies point to …
remission of the disease. The etiology of IBD is not fully understood. Many studies point to …
IL-10 constrains sphingolipid metabolism to limit inflammation
Abstract Interleukin-10 (IL-10) is a key anti-inflammatory cytokine that can limit immune cell
activation and cytokine production in innate immune cell types. Loss of IL-10 signalling …
activation and cytokine production in innate immune cell types. Loss of IL-10 signalling …
Bacteroides thetaiotaomicron Ameliorates Colon Inflammation in Preclinical Models of Crohn's Disease
M Delday, I Mulder, ET Logan… - Inflammatory bowel …, 2019 - academic.oup.com
Background Alterations in the gut microbiota are strongly associated with the development
of inflammatory bowel disease (IBD), particularly with Crohn's disease, which is …
of inflammatory bowel disease (IBD), particularly with Crohn's disease, which is …
An integrated taxonomy for monogenic inflammatory bowel disease
Background & aims Monogenic forms of inflammatory bowel disease (IBD) illustrate the
essential roles of individual genes in pathways and networks safeguarding immune …
essential roles of individual genes in pathways and networks safeguarding immune …
Tregopathies: monogenic diseases resulting in regulatory T-cell deficiency
Monogenic diseases of the immune system, also known as inborn errors of immunity, are
caused by single-gene mutations resulting in immune deficiency and dysregulation. More …
caused by single-gene mutations resulting in immune deficiency and dysregulation. More …