Light-triggered photodynamic nanomedicines for overcoming localized therapeutic efficacy in cancer treatment

J Choi, IC Sun, HS Hwang, HY Yoon, K Kim - Advanced Drug Delivery …, 2022 - Elsevier
Photodynamic nanomedicines have significantly enhanced the therapeutic efficacy of
photosensitizers (PSs) by overcoming critical limitations of PSs such as poor water solubility …

Gel formulations for topical treatment of skin cancer: A review

M Slavkova, B Tzankov, T Popova, C Voycheva - Gels, 2023 - mdpi.com
Skin cancer, with all its variations, is the most common type of cancer worldwide.
Chemotherapy by topical application is an attractive strategy because of the ease of …

Enzyme-responsive double-locked photodynamic molecular beacon for targeted photodynamic anticancer therapy

LKB Tam, JCH Chu, L He, C Yang… - Journal of the …, 2023 - ACS Publications
An advanced photodynamic molecular beacon (PMB) was designed and synthesized, in
which a distyryl boron dipyrromethene (DSBDP)-based photosensitizer and a Black Hole …

Specific activation of photosensitizer with extrinsic enzyme for precisive photodynamic therapy

J **ong, JCH Chu, WP Fong, CTT Wong… - Journal of the …, 2022 - ACS Publications
Delivery of functional proteins into the intracellular space has been a challenging task that
could lead to a myriad of therapeutic applications. We report herein a novel bioconjugation …

Recent progress in multifunctional conjugated polymer nanomaterial-based synergistic combination phototherapy for microbial infection theranostics

P Manivasagan, J Kim, ES Jang - Coordination Chemistry Reviews, 2022 - Elsevier
Microbial infection is a critical public health problem, owing to its strong infectivity and high
risk of mortality. Multi-antibiotic resistant pathogens reduce the efficacy of commercial …

[HTML][HTML] Aptamers as smart ligands for targeted drug delivery in cancer therapy

Z Wei, Y Zhou, R Wang, J Wang, Z Chen - Pharmaceutics, 2022 - mdpi.com
Undesirable side effects and multidrug tolerance are the main holdbacks to the treatment of
cancer in conventional chemotherapy. Fortunately, targeted drug delivery can improve the …

Toward precise antitumoral photodynamic therapy using a dual receptor‐mediated bioorthogonal activation approach

JCH Chu, CTT Wong, DKP Ng - … Chemie International Edition, 2023 - Wiley Online Library
Targeted delivery and specific activation of photosensitizers can greatly improve the
treatment outcome of photodynamic therapy. To this end, we report herein a novel dual …

Inducing Immunogenic Cancer Cell Death through Oxygen‐Economized Photodynamic Therapy with Nitric Oxide‐Releasing Photosensitizers

F Xu, M Wang, E Dotse, KT Chow… - Angewandte Chemie …, 2024 - Wiley Online Library
Photodynamic therapy (PDT) utilizes reactive oxygen species (ROS) for eradication of
cancer cells. Its effectiveness is governed by the oxygen content, which is scarce in the …

Nanomedicines: Emerging platforms in smart chemotherapy treatment—a recent review

M Arafat, M Sakkal, R Beiram, S AbuRuz - Pharmaceuticals, 2024 - mdpi.com
Cancer continues to pose one of the most critical challenges in global healthcare. Despite
the wide array of existing cancer drugs, the primary obstacle remains in selectively targeting …