RNA-dependent RNA polymerase (RdRp) inhibitors: The current landscape and repurposing for the COVID-19 pandemic
L Tian, T Qiang, C Liang, X Ren, M Jia, J Zhang… - European journal of …, 2021 - Elsevier
The widespread nature of several viruses is greatly credited to their rapidly altering RNA
genomes that enable the infection to persist despite challenges presented by host cells …
genomes that enable the infection to persist despite challenges presented by host cells …
Hepatitis C viral replication complex
HC Li, CH Yang, SY Lo - Viruses, 2021 - mdpi.com
The life cycle of the hepatitis C virus (HCV) can be divided into several stages, including
viral entry, protein translation, RNA replication, viral assembly, and release. HCV genomic …
viral entry, protein translation, RNA replication, viral assembly, and release. HCV genomic …
CK1 and PP1 regulate Rift Valley fever virus genome replication through L protein phosphorylation
N Bracci, A Baer, R Flor, K Petraccione, T Stocker… - Antiviral Research, 2024 - Elsevier
Rift Valley fever virus (RVFV) is an arbovirus in the Phenuiviridae family identified initially by
the large 'abortion storms' observed among ruminants; RVFV can also infect humans. In …
the large 'abortion storms' observed among ruminants; RVFV can also infect humans. In …
Akt phosphorylation of hepatitis c virus NS5B regulates polymerase activity and hepatitis c virus infection
R Sabariegos, L Albentosa-González… - Frontiers in …, 2021 - frontiersin.org
Hepatitis C virus (HCV) is a single-stranded RNA virus of positive polarity [ssRNA (+)] that
replicates its genome through the activity of one of its proteins, called NS5B. This viral …
replicates its genome through the activity of one of its proteins, called NS5B. This viral …
Phosphorylation of phylogenetically conserved amino acid residues confines HBx within different cell compartments of human hepatocarcinoma cells
C Prieto, J Montecinos, G Jiménez, C Riquelme… - Molecules, 2021 - mdpi.com
Hepatitis B virus (HBV) is a circular, and partially double-stranded DNA virus. Upon
infection, the viral genome is translocated into the cell nucleus, generating the covalently …
infection, the viral genome is translocated into the cell nucleus, generating the covalently …
Regulation of viral RNA-dependent RNA polymerases by phosphorylation
C Duflos, T Michiels - Frontiers in Virology, 2023 - frontiersin.org
RNA viruses encode an RNA-dependent RNA polymerase (RdRp), which is essential for
transcription and replication of their genome since host cells lack equivalent enzymes. RdRp …
transcription and replication of their genome since host cells lack equivalent enzymes. RdRp …
Recombinant HCV NS3 and NS5B enzymes exhibit multiple posttranslational modifications for potential regulation
Posttranslational modification (PTM) of proteins is critical to modulate protein function and to
improve the functional diversity of polypeptides. In this report, we have analyzed the PTM of …
improve the functional diversity of polypeptides. In this report, we have analyzed the PTM of …
Akt phosphorylation of HCV NS5B regulates polymerase activity and HCV infection
R Sabariegos, L Albentosa-González, B Palmero… - 2021 - digital.csic.es
Hepatitis C virus (HCV) is a single-stranded RNA virus of positive polarity [ssRNA (+)] that
replicates its genome through the activity of one of its proteins, called NS5B. This viral …
replicates its genome through the activity of one of its proteins, called NS5B. This viral …