Microfluidics for cell separation

AAS Bhagat, H Bow, HW Hou, SJ Tan, J Han… - Medical & biological …, 2010 - Springer
The need for efficient cell separation, an essential preparatory step in many biological and
medical assays, has led to the recent development of numerous microscale separation …

Dielectrophoresis in microfluidics technology

B Çetin, D Li - Electrophoresis, 2011 - Wiley Online Library
Dielectrophoresis (DEP) is the movement of a particle in a non‐uniform electric field due to
the interaction of the particle's dipole and spatial gradient of the electric field. DEP is a subtle …

Lab-on-a-chip devices for global health: Past studies and future opportunities

CD Chin, V Linder, SK Sia - Lab on a Chip, 2007 - pubs.rsc.org
A rapidly emerging field in lab-on-a-chip (LOC) research is the development of devices to
improve the health of people in develo** countries. In this review, we identify diseases …

Isolation of circulating tumor cells by dielectrophoresis

PRC Gascoyne, S Shim - Cancers, 2014 - mdpi.com
Dielectrophoresis (DEP) is an electrokinetic method that allows intrinsic dielectric properties
of suspended cells to be exploited for discrimination and separation. It has emerged as a …

Hydrodynamic mechanisms of cell and particle trap** in microfluidics

A Karimi, S Yazdi, AM Ardekani - Biomicrofluidics, 2013 - pubs.aip.org
Focusing and sorting cells and particles utilizing microfluidic phenomena have been
flourishing areas of development in recent years. These processes are largely beneficial in …

PCR microfluidic devices for DNA amplification

C Zhang, J Xu, W Ma, W Zheng - Biotechnology advances, 2006 - Elsevier
The miniaturization of biological and chemical analytical devices by micro-electro-
mechanical-systems (MEMS) technology has posed a vital influence on such fields as …

Deformability based cell margination—a simple microfluidic design for malaria-infected erythrocyte separation

HW Hou, AAS Bhagat, AGL Chong, P Mao, KSW Tan… - Lab on a Chip, 2010 - pubs.rsc.org
In blood vessels with luminal diameter less than 300μm, red blood cells (RBCs) which are
smaller in size and more deformable than leukocytes, migrate to the axial centre of the …

Current and develo** technologies for monitoring agents of bioterrorism and biowarfare

DV Lim, JM Simpson, EA Kearns… - Clinical microbiology …, 2005 - Am Soc Microbiol
Recent events have made public health officials acutely aware of the importance of rapidly
and accurately detecting acts of bioterrorism. Because bioterrorism is difficult to predict or …

Microfluidic systems for pathogen sensing: a review

J Mairhofer, K Roppert, P Ertl - Sensors, 2009 - mdpi.com
Rapid pathogen sensing remains a pressing issue today since conventional identification
methodsare tedious, cost intensive and time consuming, typically requiring from 48 to 72 h …

Microfluidic-based biosensors toward point-of-care detection of nucleic acids and proteins

S Choi, M Goryll, LYM Sin, PK Wong, J Chae - Microfluidics and …, 2011 - Springer
This article reviews state-of-the-art microfluidic biosensors of nucleic acids and proteins for
point-of-care (POC) diagnostics. Microfluidics is capable of analyzing small sample volumes …