Epigenetic regulation of the innate immune response to infection

Q Zhang, X Cao - Nature Reviews Immunology, 2019 - nature.com
Innate immune cells have complex signalling pathways for sensing pathogens and initiating
innate immune responses against infection. These pathways are tightly regulated at different …

Epigenetic remodeling in innate immunity and inflammation

Q Zhang, X Cao - Annual review of immunology, 2021 - annualreviews.org
The innate immune response is a rapid response to pathogens or danger signals. It is
precisely activated not only to efficiently eliminate pathogens but also to avoid excessive …

Histone acetyltransferase 1 is a succinyltransferase for histones and non‐histones and promotes tumorigenesis

G Yang, Y Yuan, H Yuan, J Wang, H Yun, Y Geng… - EMBO …, 2021 - embopress.org
Lysine succinylation (Ksucc) is an evolutionarily conserved and widespread post‐
translational modification. Histone acetyltransferase 1 (HAT1) is a type B histone …

Histone acetyltransferase 1 promotes gemcitabine resistance by regulating the PVT1/EZH2 complex in pancreatic cancer

Y Sun, D Ren, Y Zhou, J Shen, H Wu, X ** - Cell Death & Disease, 2021 - nature.com
The poor prognosis of pancreatic cancer is primarily due to the development of resistance to
therapies, including gemcitabine. The long noncoding RNA PVT1 (lncRNA PVT1) has been …

Histone acetylation dynamics integrates metabolic activity to regulate plant response to stress

Y Hu, Y Lu, Y Zhao, DX Zhou - Frontiers in plant science, 2019 - frontiersin.org
Histone lysine acetylation is an essential chromatin modification for epigenetic regulation of
gene expression during plant response to stress. On the other hand, enzymes involved in …

Identification of a histone family gene signature for predicting the prognosis of cervical cancer patients

X Li, R Tian, H Gao, Y Yang, BRG Williams… - Scientific reports, 2017 - nature.com
Heterogeneity in terms of tumor characteristics, prognosis, and survival among cancer
patients is an unsolved issue. Here, we systematically analyzed the aberrant expression …

Differential responses by human respiratory epithelial cell lines to respiratory syncytial virus reflect distinct patterns of infection control

P Hillyer, R Shepard, M Uehling, M Krenz… - Journal of …, 2018 - Am Soc Microbiol
Respiratory syncytial virus (RSV) infects small foci of respiratory epithelial cells via infected
droplets. Infection induces expression of type I and III interferons (IFNs) and proinflammatory …

Epigenetic regulation of inflammation: The metabolomics connection

S Rath, YM Hawsawi, F Alzahrani, MI Khan - Seminars in Cell & …, 2024 - Elsevier
Epigenetic factors are considered the regulator of complex machinery behind inflammatory
disorders and significantly contributed to the expression of inflammation-associated genes …

The role of Ca2+-signaling in the regulation of epigenetic mechanisms

A Hernández-Oliveras, A Zarain-Herzberg - Cell Calcium, 2024 - Elsevier
Epigenetic mechanisms regulate multiple cell functions like gene expression and chromatin
conformation and stability, and its misregulation could lead to several diseases including …

Fish antiviral tripartite motif (TRIM) proteins

C Langevin, JP Levraud, P Boudinot - Fish & shellfish immunology, 2019 - Elsevier
Tripartite motif (TRIM) family or RBCC proteins comprises characteristic zinc‐binding
domains (a RING (R), a B‐box type 1 (B1) and a B‐box type 2 (B2)) and coiled‐coil (CC) …