Type 2 diabetes mellitus patients have a markedly higher risk of develo** dementia. While
multiple factors contribute to this predisposition, one of these involves the increased …

Amyloidosis is a group of diseases in which proteins become amyloid, an insoluble fibrillar
aggregate, resulting in organ dysfunction. Amyloid deposition has been reported in various …

In patients with type 2 diabetes, pancreatic beta cells progressively degenerate and
gradually lose their ability to produce insulin and regulate blood glucose. Beta cell …

The pancreatic islet vasculature comprises microvascular endothelial cells surrounded by
mural cells (pericytes). Both cell types support the islet by providing (1) a conduit for delivery …

For many years, it has been taught in medical textbooks that the endocrine and exocrine
parts of the pancreas have separate blood supplies that do not mix. Therefore, they have …

Diabetes is not only an endocrine but also a vascular disease. Vascular defects are usually
seen as consequence of diabetes. However, at the level of the pancreatic islet, vascular …

Diseases characterized by amyloid aggregation, including Alzheimer's disease, Parkinson's
disease, Huntington's disease, and Type Ⅱ Diabetes mellitus, present a significant global …

Purpose: In this study, we identified differentially expressed genes (DEGs) and signaling
pathways to gain insight into the pathogenesis of acute lung injury (ALI). Methods: C57BL/6 …

Aims/hypothesis Apart from its fibrinolytic activity, the tissue plasminogen activator
(tPA)/plasmin system has been reported to cleave the peptide amyloid beta, attenuating …

Islets of Langerhans are anatomically dispersed within the pancreas and exhibit regulatory
coordination between islets in response to nutritional and inflammatory stimuli. However …