The transient specificity pocket of aldose reductase only opens in response to specific
ligands. This pocket may offer an advantage for the development of novel, more selective …

AKR1B10 is a member of the human aldo–keto reductase superfamily which is highly
expressed in several types of cancers, and has been regarded as a promising cancer …

Simple Summary The increased glucose levels occurring in diabetes lead to several
metabolic alterations responsible for the onset of the so-called diabetic complications, which …

Protozoan diseases such as malaria, African trypanosomiasis (slee** sickness),
toxoplasmosis, and leishmaniasis are a major cause of human mortality, morbidity, and …

Toxicity is one of the main causes of failure during drug discovery, and of withdrawal once
drugs reached the market. Prediction of potential toxicities in the early stage of drug …