Dyslipidemia is an important risk factor for coronary artery disease and stroke. All persons
with dyslipidemia should be advised to focus on lifestyle interventions, including regular …

Cardiovascular diseases (CVDs) are the leading cause of premature death and disability in
humans and their incidence is on the rise globally. Given their substantial contribution …

Lipid disorders involving derangements in serum cholesterol, triglycerides, or both are
commonly encountered in clinical practice and often have implications for cardiovascular …

Surveys and registries are needed to verify that real-life daily practice is in kee** with what
is recommended in the guidelines, thus completing the loop between clinical research …

Abstract Purpose of Review Mendelian randomization (MR) is a strategy for evaluating
causality in observational epidemiological studies. MR exploits the fact that genotypes are …

Lowering blood cholesterol levels efficiently reduces the risk of develo** atherosclerotic
cardiovascular disease (ASCVD), including coronary artery disease (CAD), which is the …

Over the last 3 decades there have been substantial improvements in treatments aimed at
reducing cardiovascular (CV) events. As these treatments have been developed, there have …

With cardiovascular disease being the leading cause of morbidity and mortality worldwide,
effective and cost-efficient therapies to reduce cardiovascular risk are highly needed. Lipids …

Importance Effects on specific fatal and nonfatal end points appear to vary for low-density
lipoprotein cholesterol (LDL-C)–lowering drug trials. Objective To evaluate whether baseline …

Efficient genome editing with Cas9–sgRNA in vivo has required the use of viral delivery
systems, which have limitations for clinical applications. Translational efforts to develop …