One of the most common monogenic forms of Parkinson disease (PD) is caused by
mutations in the LRRK2 gene that encodes leucine-rich repeat kinase 2 (LRRK2). LRRK2 …

Over 20 years ago, the synaptic protein α-synuclein was identified as the primary component
of the Lewy bodies (LBs) that are a sine qua non of Parkinson's disease (PD). Since that …

Studies of patients afflicted by neurodegenerative diseases suggest that misfolded proteins
spread through the brain along anatomically connected networks, prompting progressive …

It has been 15 years since the Leucine-rich repeat kinase 2 (LRRK2) gene was identified as
the most common genetic cause for Parkinson's disease (PD). The two most common …

Parkinson's disease is a progressive neurodegenerative disorder characterised by the
accumulation of misfolded α-synuclein in selected brain regions, including the substantia …

Autosomal dominant missense mutations that hyperactivate the leucine-rich repeat protein
kinase-2 (LRRK2) are a common cause of inherited Parkinson's disease and therapeutic …

Antibodies against phosphorylated alpha-synuclein (aSyn) at S129 have emerged as the
primary tools to investigate, monitor, and quantify aSyn pathology in the brain and peripheral …

Leucine-rich repeat kinase 2 (LRRK2) is a multifunctional protein that orchestrates a diverse
array of cellular processes, including vesicle transport, autophagy, lysosome degradation …

In Parkinson's disease (PD), and other α-synucleinopathies, α-synuclein (α-Syn) aggregates
form a myriad of conformational and truncational variants. Most antibodies used to detect …

Background Mutations in leucine-rich repeat kinase 2 (LRRK2) are the most common cause
of familial Parkinson's disease (PD). These mutations elevate the LRRK2 kinase activity …