Twenty years on: the impact of fragments on drug discovery
DA Erlanson, SW Fesik, RE Hubbard… - Nature reviews Drug …, 2016 - nature.com
After 20 years of sometimes quiet growth, fragment-based drug discovery (FBDD) has
become mainstream. More than 30 drug candidates derived from fragments have entered …
become mainstream. More than 30 drug candidates derived from fragments have entered …
Open Science holds the promise to make scientific endeavours more inclusive, participatory,
understandable, accessible and re-usable for large audiences. However, making processes …
understandable, accessible and re-usable for large audiences. However, making processes …
The influence of lipophilicity in drug discovery and design
Introduction: The role of lipophilicity in drug discovery and design is a critical one.
Lipophilicity is a key physicochemical property that plays a crucial role in determining …
Lipophilicity is a key physicochemical property that plays a crucial role in determining …
[HTML][HTML] Current challenges and future perspectives in oral absorption research: An opinion of the UNGAP network
Although oral drug delivery is the preferred administration route and has been used for
centuries, modern drug discovery and development pipelines challenge conventional …
centuries, modern drug discovery and development pipelines challenge conventional …
The'rule of three'for fragment-based drug discovery: where are we now?
H Jhoti, G Williams, DC Rees, CW Murray - Nature Reviews Drug …, 2013 - nature.com
© 2013 Macmillan Publishers Limited. All rights reserved and the nature of the
measurements. Among the many reasons for the discrepancy, only about 5% of a fragment …
measurements. Among the many reasons for the discrepancy, only about 5% of a fragment …
Finding the sweet spot: the role of nature and nurture in medicinal chemistry
Given its position at the heart of small-molecule drug discovery, medicinal chemistry has an
important role in tackling the well-known productivity challenges in pharmaceutical research …
important role in tackling the well-known productivity challenges in pharmaceutical research …