Drug discovery and development are aimed at identifying new chemical molecular entities
(NCEs) with desirable pharmacokinetic profiles for high therapeutic efficacy. The plasma …

ABC transporters play a critical role in both drug bioavailability and toxicity, and with the
discovery of the P-glycoprotein (P-gp), this became even more evident, as it plays an …

The emergence of the severe acute respiratory syndrome coronavirus‐2 (SARS‐CoV‐2)
with the most contagious variants, alpha (B. 1.1. 7), beta (B. 1.351), delta (B. 1.617. 2), and …

Targeting the signaling pathway of the Vascular endothelial growth factor receptor-2 is a
promising approach that has drawn attention in the quest to develop novel anti-cancer drugs …

The SARS-CoV-2 3CLpro is a critical target for COVID-19 therapeutics due to its role in viral
replication. We employed a screening pipeline to identify novel inhibitors by combining …

The efflux transporter P-glycoprotein (P-gp) is responsible for the extrusion of a wide variety
of molecules, including drug molecules, from the cell. Therefore, P-gp-mediated efflux …

Elesclomol (ES), a copper-binding ionophore, forms an ES–Cu complex with copper ions
(Cu (II)). ES–Cu has been proven to induce mitochondrial oxidative stress and copper …

Oral administration is the preferred and predominant route of choice for medication. As such,
drug absorption is one of critical drug metabolism and pharmacokinetics (DM/PK) …

The heterogeneity of the Caco-2 cell line and differences in experimental protocols for
permeability assessment using this cell-based method have resulted in the high variability of …

Toxoplasmosis is a zoonotic disease caused by Toxoplasma gondii, an apicomplexan
parasite that infects approximately a third of the world's human population. This disease can …