RNAs and RNA-binding proteins can undergo spontaneous or active condensation into
phase-separated liquid-like droplets. These condensates are cellular hubs for various …

Biomolecular condensates are dynamic membraneless organelles that compartmentalize
proteins and RNA molecules to regulate key cellular processes. Diverse RNA species exert …

Biomolecular condensates form via processes that combine phase separation and
reversible associations of multivalent macromolecules. Condensates can be two-or …

The functions of biomolecular condensates are thought to be influenced by their material
properties, and these will be determined by the internal organization of molecules within …

The internal microenvironment of a living cell is heterogeneous and comprises a multitude of
organelles with distinct biochemistry. Amongst them are biomolecular condensates, which …

Cells use membraneless compartments to organize their interiors, and recent research has
begun to uncover the molecular principles underlying their assembly. Here, we explore how …

Under certain conditions, RNA repeat sequences phase separate, yielding protein-free
biomolecular condensates. Importantly, RNA repeat sequences have also been implicated …

The nucleolus is the largest membraneless organelle and nuclear body in mammalian cells.
It is primarily involved in the biogenesis of ribosomes, essential macromolecular machines …

In higher eukaryotes, the nucleolus harbors at least three sub-phases that facilitate multiple
functionalities including ribosome biogenesis. The three prominent coexisting sub-phases …

Cellular senescence, which is triggered by various stressors, manifests as irreversible cell
cycle arrest, resulting in the disruption of multiple nuclear condensates. One of the affected …