There is consistent evidence that brain volume changes in early and late life. Most
longitudinal studies usually only span a few years and include a limited number of …

Objective: Schizophrenia is a devastating mental disorder accompanied by aberrant
structural brain connectivity. The question whether schizophrenia is a progressive brain …

Background It is well established that schizophrenia is associated with structural brain
abnormalities, but whether these are static or progress over time remains controversial …

Context Hippocampal volume is lower than expected in patients with schizophrenia;
however, whether this represents a fixed deficit is uncertain. Exercise is a stimulus to …

Background Psychotic disorders, such as schizophrenia, are associated with
neuroanatomical abnormalities, but whether these predate the onset of symptoms or …

BackgroundStudies of people with schizophrenia assessed using magnetic resonance
imaging (MRI) usually include patients with first-episode and chronic disease, yet brain …

The underlying neurobiology of emerging psychotic disorders is not well understood. While
there is evidence from structural imaging and other studies supporting the popular notion …

Background Pathomorphologic brain changes occurring as early as first-episode
schizophrenia have been extensively described. Longitudinal studies have demonstrated …

Context Magnetic resonance imaging studies have identified hippocampal volume
reductions in schizophrenia and amygdala volume enlargements in bipolar disorder …

Background Many studies have shown that structural brain abnormalities in schizophrenia
are already present by the time of index evaluation of first-episode patients. However …