Black cumin (Nigella sativa) and its active constituent, thymoquinone: an overview on the analgesic and anti-inflammatory effects

B Amin, H Hosseinzadeh - Planta medica, 2016 - thieme-connect.com
For many centuries, seeds of Nigella sativa (black cumin), a dicotyledon of the
Ranunculaceae family, have been used as a seasoning spice and food additive in the …

Nigella sativa Linn.– A comprehensive review

PM Paarakh - 2010 - nopr.niscpr.res.in
Nigella sativa Linn.(Family-Ranunculaceae) is a widely used medicinal plant throughout
India and popular in various Indigenous System of Medicine like Ayurveda, Siddha, Unani …

Review on molecular and therapeutic potential of thymoquinone in cancer

S Banerjee, S Padhye, A Azmi, Z Wang… - Nutrition and …, 2010 - Taylor & Francis
Thymoquinone (TQ) is the predominant bioactive constituent present in black seed oil
(Nigella sativa) and has been tested for its efficacy against cancer. Here, we summarize the …

Antioxidant thymoquinone and its potential in the treatment of neurological diseases

NK Isaev, EE Genrikhs, EV Stelmashook - Antioxidants, 2023 - mdpi.com
Oxidative stress is one of the main pathogenic factors of neuron damage in
neurodegenerative processes; this makes it an important therapeutic target to which the …

Mechanism of the antidiabetic action of Nigella sativa and Thymoquinone: a review

A Shaukat, A Zaidi, H Anwar, N Kizilbash - Frontiers in Nutrition, 2023 - frontiersin.org
Introduction Long used in traditional medicine, Nigella sativa (NS; Ranunculaceae) has
shown significant efficacy as an adjuvant therapy for diabetes mellitus (DM) management by …

Effects of the hydro-alcoholic extract of Nigella sativa on scopolamine-induced spatial memory impairment in rats and its possible mechanism

M Hosseini, T Mohammadpour, R Karami… - Chinese journal of …, 2015 - Springer
Objective To evaluate the effect of Nigella sativa (NS) extract on memory performance and
its possible mechanisms in scopolamine (Sco)-induced spatial memory impairment model …

Neuroprotection with metformin and thymoquinone against ethanol-induced apoptotic neurodegeneration in prenatal rat cortical neurons

I Ullah, N Ullah, MI Naseer, HY Lee, MOK Kim - BMC neuroscience, 2012 - Springer
Background Exposure to ethanol during early development triggers severe neuronal death
by activating multiple stress pathways and causes neurological disorders, such as fetal …

Neuroprotective effect of thymoquinone, the nigella sativa bioactive compound, in 6-hydroxydopamine-induced hemi-parkinsonian rat model

R Sedaghat, M Roghani… - Iranian journal of …, 2014 - pmc.ncbi.nlm.nih.gov
Parkinson disease (PD) is the most common movement disorder with progressive
degeneration of midbrain dopaminergic neurons for which current treatments afford …

Neuropharmacological potential and delivery prospects of thymoquinone for neurological disorders

M Jakaria, DY Cho, M Ezazul Haque… - Oxidative medicine …, 2018 - Wiley Online Library
Thymoquinone (TQ) is an active ingredient isolated from Nigella sativa and has various
pharmacological activities, such as protection against oxidative stress, inflammation, and …

Amelioration of neurodegenerative changes in cellular and rat models of diabetes-related Alzheimer's disease by exendin-4

S Chen, A Liu, F An, W Yao, X Gao - Age, 2012 - Springer
Growing evidence suggests that type 2 diabetes mellitus (DM) is associated with age-
dependent Alzheimer's disease (AD), the latter of which has even been considered as type 3 …