Double-stranded RNA sensors and modulators in innate immunity
S Hur - Annual review of immunology, 2019 - annualreviews.org
Detection of double-stranded RNAs (dsRNAs) is a central mechanism of innate immune
defense in many organisms. We here discuss several families of dsRNA-binding proteins …
defense in many organisms. We here discuss several families of dsRNA-binding proteins …
Liquid-liquid phase separation of TDP-43 and FUS in physiology and pathology of neurodegenerative diseases
JL Carey, L Guo - Frontiers in molecular biosciences, 2022 - frontiersin.org
Liquid-liquid phase separation of RNA-binding proteins mediates the formation of numerous
membraneless organelles with essential cellular function. However, aberrant phase …
membraneless organelles with essential cellular function. However, aberrant phase …
[HTML][HTML] G3BP1 is a tunable switch that triggers phase separation to assemble stress granules
The mechanisms underlying ribonucleoprotein (RNP) granule assembly, including the basis
for establishing and maintaining RNP granules with distinct composition, are unknown. One …
for establishing and maintaining RNP granules with distinct composition, are unknown. One …
Prenatal androgen exposure and transgenerational susceptibility to polycystic ovary syndrome
How obesity and elevated androgen levels in women with polycystic ovary syndrome
(PCOS) affect their offspring is unclear. In a Swedish nationwide register-based cohort and a …
(PCOS) affect their offspring is unclear. In a Swedish nationwide register-based cohort and a …
Disruption of RNA metabolism in neurological diseases and emerging therapeutic interventions
RNA binding proteins are critical to the maintenance of the transcriptome via controlled
regulation of RNA processing and transport. Alterations of these proteins impact multiple …
regulation of RNA processing and transport. Alterations of these proteins impact multiple …
Predicting dynamic cellular protein–RNA interactions by deep learning using in vivo RNA structures
L Sun, K Xu, W Huang, YT Yang, P Li, L Tang, T ** and exon-resolution functional genomics with a hybrid Cas9–Cas12a platform
Systematic map** of genetic interactions (GIs) and interrogation of the functions of sizable
genomic segments in mammalian cells represent important goals of biomedical research. To …
genomic segments in mammalian cells represent important goals of biomedical research. To …
Dance with the devil: stress granules and signaling in antiviral responses
N Eiermann, K Haneke, Z Sun, G Stoecklin, A Ruggieri - Viruses, 2020 - mdpi.com
Cells have evolved highly specialized sentinels that detect viral infection and elicit an
antiviral response. Among these, the stress-sensing protein kinase R, which is activated by …
antiviral response. Among these, the stress-sensing protein kinase R, which is activated by …
Decoding protein–RNA interactions using CLIP-based methodologies
Protein–RNA interactions are central to all RNA processing events, with pivotal roles in the
regulation of gene expression and cellular functions. Dysregulation of these interactions has …
regulation of gene expression and cellular functions. Dysregulation of these interactions has …
Analysis of RNA–protein networks with RNP-MaP defines functional hubs on RNA
RNA–protein interaction networks govern many biological processes but are difficult to
examine comprehensively. We devised ribonucleoprotein networks analyzed by mutational …
examine comprehensively. We devised ribonucleoprotein networks analyzed by mutational …