Hierarchical classification of glycoside hydrolases
DG Naumoff - Biochemistry (Moscow), 2011 - Springer
This review deals with structural and functional features of glycoside hydrolases, a
widespread group of enzymes present in almost all living organisms. Their catalytic domains …
widespread group of enzymes present in almost all living organisms. Their catalytic domains …
Catalytic Versatility, Stability, and Evolution of the (βα)8-Barrel Enzyme Fold
R Sterner, B Höcker - Chemical Reviews, 2005 - ACS Publications
Natural evolution has yielded enzymes that catalyze virtually all metabolic reactions under
mild conditions with high specificities and enormous rate enhancements. 1 It has been a …
mild conditions with high specificities and enormous rate enhancements. 1 It has been a …
A vocabulary of ancient peptides at the origin of folded proteins
The seemingly limitless diversity of proteins in nature arose from only a few thousand
domain prototypes, but the origin of these themselves has remained unclear. We are …
domain prototypes, but the origin of these themselves has remained unclear. We are …
Evolution of function in (β/α) 8-barrel enzymes
JA Gerlt, FM Raushel - Current opinion in chemical biology, 2003 - Elsevier
The (β/α) 8-barrel is the most common fold in structurally characterized enzymes. Whether
the functionally diverse enzymes that share this fold are the products of either divergent or …
the functionally diverse enzymes that share this fold are the products of either divergent or …
Exploiting enzyme evolution for computational protein design
Recent years have seen an explosion of interest in understanding the physicochemical
parameters that shape enzyme evolution, as well as substantial advances in computational …
parameters that shape enzyme evolution, as well as substantial advances in computational …
Mimicking enzyme evolution by generating new (βα)8-barrels from (βα)4-half-barrels
B Höcker, J Claren, R Sterner - Proceedings of the National …, 2004 - National Acad Sciences
Gene duplication and fusion events that multiply and link functional protein domains are
crucial mechanisms of enzyme evolution. The analysis of amino acid sequences and three …
crucial mechanisms of enzyme evolution. The analysis of amino acid sequences and three …
[HTML][HTML] Identification and analysis of natural building blocks for evolution-guided fragment-based protein design
Natural evolution has generated an impressively diverse protein universe via duplication
and recombination from a set of protein fragments that served as building blocks. The …
and recombination from a set of protein fragments that served as building blocks. The …
AdoMet radical proteins—from structure to evolution—alignment of divergent protein sequences reveals strong secondary structure element conservation
Y Nicolet, CL Drennan - Nucleic acids research, 2004 - academic.oup.com
Eighteen subclasses of S-adenosyl-l-methionine (AdoMet) radical proteins have been
aligned in the first bioinformatics study of the AdoMet radical superfamily to utilize …
aligned in the first bioinformatics study of the AdoMet radical superfamily to utilize …
Evolutionary relationship of two ancient protein superfolds
Proteins are the molecular machines of the cell that fold into specific three-dimensional
structures to fulfill their functions. To improve our understanding of how the structure and …
structures to fulfill their functions. To improve our understanding of how the structure and …
From ancestral peptides to designed proteins
Highlights•Domains may not represent the only unit of protein structure.•The first folded
proteins are likely to have evolved from simple peptides in an ancient RNA-peptide …
proteins are likely to have evolved from simple peptides in an ancient RNA-peptide …