A large proportion of protein–protein interactions (PPIs) occur between a short peptide and a
globular protein domain; the peptides involved in surface interactions play important roles …

Protein–protein interactions (PPIs) are involved at all levels of cellular organization, thus
making the development of PPI inhibitors extremely valuable. The identification of selective …

The clinical translation of cationic α-helical antimicrobial peptides (AMPs) has been
hindered by structural instability, proteolytic degradation and in vivo toxicity from nonspecific …

Our ever‐increasing understanding of biological systems is providing a range of exciting
novel biological targets, whose modulation may enable novel therapeutic options for many …

Peptide-based drug discovery has experienced a significant upturn within the past decade
since the introduction of chemical modifications and unnatural amino acids has allowed for …

Hydrocarbon-stapled peptides are a class of bioactive alpha-helical ligands developed to
dissect and target protein interactions. While there is consensus that stapled peptides can …

Abstract Protein‐Protein‐Interaktionen (PPIs) spielen auf allen Ebenen der Zellorganisation
eine wichtige Rolle, was die Entwicklung von PPI‐Inhibitoren äußerst interessant macht. Die …

Activating mutations in the Kirsten rat sarcoma viral oncogene homolog (KRAS) underlie the
pathogenesis and chemoresistance of∼ 30% of all human tumors, yet the development of …

Conformationally stabilized α-helical peptides are capable of inhibiting disease-relevant
intracellular or extracellular protein–protein interactions in vivo. We have previously reported …

Highlights•One of the most widely adopted strategies for α-helix stabilisation is peptide
stapling.•Stapled peptides are highly promising therapeutic agents.•General design …