Pyrazolone is a well-known influential synthon for the synthesis of many molecules which
hold remarkable potential in the advancement of functional materials, coordination …

Pyrazole has been the topic of interest for thousands of researchers across the world
because of its wide spectrum pharmacological activities. Various structural modifications of …

The combretastatins are isolated from South African tree combretum caffrum kuntze. The
lead compound combretastatin A-4 has displayed remarkable cytotoxic effect in a wide …

Dihydropyrazole (1–22) derivatives were synthesized from already synthesized chalcones.
The structures of all of the synthesized compounds were confirmed by elemental analysis …

A series of both novel and reported combretastatin analogues, including diarylpyrazoles,-
isoxazoles,-1, 2, 3-triazoles, and-pyrroles, were synthesized via improved protocols to …

Due to the three domains of the colchicine-site which is conducive to the combination with
small molecule compounds, colchicine-site on the tubulin has become a common target for …

Abstract A series of 1, 5-diaryl-and 4, 5-diaryl-1, 2, 3-triazole derivatives of combretastatin A4
were synthesized and evaluated as antimitotic microtubule destabilizing agents using the …

Tubulin protein is a highly imperative and feasible goal for anticancer drug discovery.
Hundreds of naturally occurring, semi synthetic and synthetic antitubulin agents have been …

In this study, new dibenzensulfonamides, 7–9, having the chemical structure 4, 4′-(5′-
chloro-3′-methyl-5-aryl-3, 4-dihydro-1′ H, H-[3, 4′-bipyrazole]-1′, 2-diyl) …

Pyrazolone is a five-membered lactam ring containing two Nitrogens and one ketonic group
in its structure. Numerous pyrazolone derivatives were exhibited with diverse biological …