[HTML][HTML] Approaches, progress, and challenges to hepatitis C vaccine development

JR Bailey, E Barnes, AL Cox - Gastroenterology, 2019 - Elsevier
Risk factors for hepatitis C virus (HCV) infection vary, and there were an estimated 1.75
million new cases worldwide in 2015. The World Health Organization aims for a 90 …

Immune responses and immunopathology in acute and chronic viral hepatitis

EC Shin, PS Sung, SH Park - Nature Reviews Immunology, 2016 - nature.com
Hepatitis A virus (HAV), hepatitis B virus (HBV) and hepatitis C virus (HCV) are responsible
for most cases of viral hepatitis. Infection by each type of virus results in a different typical …

CD39 Expression Identifies Terminally Exhausted CD8+ T Cells

PK Gupta, J Godec, D Wolski, E Adland, K Yates… - PLoS …, 2015 - journals.plos.org
Exhausted T cells express multiple co-inhibitory molecules that impair their function and limit
immunity to chronic viral infection. Defining novel markers of exhaustion is important both for …

The history of hepatitis C virus (HCV): Basic research reveals unique features in phylogeny, evolution and the viral life cycle with new perspectives for epidemic control

J Bukh - Journal of hepatology, 2016 - Elsevier
The discovery of hepatitis C virus (HCV) in 1989 permitted basic research to unravel critical
components of a complex life cycle for this important human pathogen. HCV is a highly …

[HTML][HTML] Innate and adaptive immune responses in HCV infections

MH Heim, R Thimme - Journal of hepatology, 2014 - Elsevier
Hepatitis C virus has been identified a quarter of a decade ago as a leading cause of
chronic viral hepatitis that can lead to cirrhosis and hepatocellular carcinoma. Only a …

Immunology of hepatitis B virus and hepatitis C virus infection

B Rehermann, M Nascimbeni - Nature Reviews Immunology, 2005 - nature.com
More than 500 million people worldwide are persistently infected with the hepatitis B virus
(HBV) and/or hepatitis C virus (HCV) and are at risk of develo** chronic liver disease …

Robust hepatitis C virus infection in vitro

J Zhong, P Gastaminza, G Cheng, S Kapadia… - Proceedings of the …, 2005 - pnas.org
The absence of a robust cell culture model of hepatitis C virus (HCV) infection has severely
limited analysis of the HCV life cycle and the development of effective antivirals and …

Immunobiology and pathogenesis of viral hepatitis

LG Guidotti, FV Chisari - Annu. Rev. Pathol. Mech. Dis., 2006 - annualreviews.org
Among the many viruses that are known to infect the human liver, hepatitis B virus (HBV)
and hepatitis C virus (HCV) are unique because of their prodigious capacity to cause …

Unravelling hepatitis C virus replication from genome to function

BD Lindenbach, CM Rice - Nature, 2005 - nature.com
Since the discovery of the hepatitis C virus over 15 years ago, scientists have raced to
develop diagnostics, study the virus and find new therapies. Yet virtually every attempt to …

[PDF][PDF] Clearance of hepatitis C infection is associated with the early appearance of broad neutralizing antibody responses

WO Osburn, AE Snider, BL Wells, R Latanich… - …, 2014 - Wiley Online Library
The contribution of humoral immune responses to spontaneous control of hepatitis C virus
(HCV) infection remains unclear. We assessed neutralizing antibody (nAb) responses …