The NOTCH gene was identified approximately 110 years ago. Classical studies have
revealed that NOTCH signaling is an evolutionarily conserved pathway. NOTCH receptors …

A defining feature of biology is the use of a multiscale architecture, ranging from molecular
networks to cells, tissues, organs, whole bodies, and swarms. Crucially however, biology is …

Animals display substantial inter-species variation in the rate of embryonic development
despite a broad conservation of the overall sequence of developmental events. Differences …

Stem-cell differentiation to desired lineages requires navigating alternating developmental
paths that often lead to unwanted cell types. Hence, comprehensive developmental …

The Notch signaling pathway comprises multiple ligands that are used in distinct biological
contexts. In principle, different ligands could activate distinct target programs in signal …

Retinoic acid (RA) is a vitamin A-derived, non-peptidic, small lipophilic molecule that acts as
ligand for nuclear RA receptors (RARs), converting them from transcriptional repressors to …

The Notch signalling pathway is evolutionarily conserved and is crucial for the development
and homeostasis of most tissues. Deregulated Notch signalling leads to various diseases …

Segmentation of the paraxial mesoderm is a major event of vertebrate development that
establishes the metameric patterning of the body axis. This process involves the periodic …

Axial development of mammals involves coordinated morphogenetic events, including axial
elongation, somitogenesis, and neural tube formation. To gain insight into the signals …

Background Congenital scoliosis is a common type of vertebral malformation. Genetic
susceptibility has been implicated in congenital scoliosis. Methods We evaluated 161 Han …