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[HTML][HTML] Chloride channels in the lung: Challenges and perspectives for viral infections, pulmonary arterial hypertension, and cystic fibrosis
Fine control over chloride homeostasis in the lung is required to maintain membrane
excitability, transepithelial transport as well as intra-and extracellular ion and water …
excitability, transepithelial transport as well as intra-and extracellular ion and water …
The plasma membrane inner leaflet PI(4,5)P2 is essential for the activation of proton-activated chloride channels
W Ko, E Lee, JE Kim, HH Lim, BC Suh - Nature Communications, 2024 - nature.com
Proton-activated chloride (PAC) channels, ubiquitously expressed in tissues, regulate
intracellular Cl-levels and cell death following acidosis. However, molecular mechanisms …
intracellular Cl-levels and cell death following acidosis. However, molecular mechanisms …
Molecular determinants of pH sensing in the proton-activated chloride channel
In response to acidic pH, the widely expressed proton-activated chloride (PAC) channel
opens and conducts anions across cellular membranes. By doing so, PAC plays an …
opens and conducts anions across cellular membranes. By doing so, PAC plays an …
Identification of the acid-sensitive site critical for chloral hydrate (CH) activation of the proton-activated chloride channel
XY Xu, FF Zhang, J Gan, MY Zhang, ZS Shen… - Journal of …, 2023 - jneurosci.org
The transmembrane protein TMEM206 was recently identified as the molecular basis of the
extracellular proton-activated Cl− channel (PAC), which plays an essential role in neuronal …
extracellular proton-activated Cl− channel (PAC), which plays an essential role in neuronal …
Physiological Functions of the Volume-Regulated Anion Channel VRAC/LRRC8 and the Proton-Activated Chloride Channel ASOR/TMEM206
Volume-regulated anion channels (VRACs) and the acid-sensitive outwardly rectifying anion
channel (ASOR) mediate flux of chloride and small organic anions. Although known for a …
channel (ASOR) mediate flux of chloride and small organic anions. Although known for a …
Immunologische Untersuchungen zur Bedeutung von bakteriellen Polyphosphaten bei Wirt-Pathogen-Interaktionen
K Brück - openscience.ub.uni-mainz.de
Polyphosphate sind langkettige, negativ geladene Polymere aus Orthophosphaten und ein
wichtiger Bestandteil des bakteriellen Stoffwechsels. Darüber hinaus interferieren …
wichtiger Bestandteil des bakteriellen Stoffwechsels. Darüber hinaus interferieren …