Glioblastomas are the most common form of malignant primary brain tumor and an important
cause of morbidity and mortality. In recent years there have been important advances in …

The WHO 2007 glioma classification system (based primarily on tumour histology) resulted
in considerable interobserver variability and substantial variation in patient survival within …

Primary brain tumors account for~ 1% of new cancer cases and~ 2% of cancer deaths in the
United States; however, they are the most commonly occurring solid tumors in children …

Abstract Purpose of Review Brain and other central nervous system (CNS) tumors, while
rare, cause significant morbidity and mortality across all ages. This article summarizes the …

Establishing causal links between inherited polymorphisms and cancer risk is challenging.
Here, we focus on the single-nucleotide polymorphism rs55705857, which confers a sixfold …

Background Accurate and noninvasive detection of isocitrate dehydrogenase (IDH,
including IDH1 and IDH2) status is clinically meaningful for molecular stratification of glioma …

Early and functional map**-guided surgery is currently the first treatment in DLGG.
Surgical resection (s) should be integrated in a global personalized management that must …

Understanding of the epidemiology of central nervous system (CNS) tumors has grown
substantially in the past 2 decades. Surveillance systems in the United States and …

Background Approximately 10% of IDH-mutant gliomas harbour non-canonical IDH
mutations (non-p. R132H IDH1 and IDH2 mutations). Objective The aim of this study was to …

Background Telomere maintenance is increasingly recognized as being fundamental to
glioma oncogenesis with longer leukocyte telomere length (LTL) reported to increase risk of …