The Ras superfamily of small GTPases: the unlocked secrets
The Ras superfamily of small GTPases is composed of more than 150 members, which
share a conserved structure and biochemical properties, acting as binary molecular …
share a conserved structure and biochemical properties, acting as binary molecular …
A new hypothesis for Parkinson's disease pathogenesis: GTPase-p38 MAPK signaling and autophagy as convergence points of etiology and genomics
The combination of genetics and genomics in Parkinson´ s disease has recently begun to
unveil molecular mechanisms possibly underlying disease onset and progression. In …
unveil molecular mechanisms possibly underlying disease onset and progression. In …
The ras superfamily of small gtpases in non-neoplastic cerebral diseases
L Qu, C Pan, SM He, B Lang, GD Gao… - Frontiers in molecular …, 2019 - frontiersin.org
The small GTPases from the Ras superfamily play crucial roles in basic cellular processes
during practically the entire process of neurodevelopment, including neurogenesis …
during practically the entire process of neurodevelopment, including neurogenesis …
RIT1 oncoproteins escape LZTR1-mediated proteolysis
RIT1 oncoproteins have emerged as an etiologic factor in Noonan syndrome and cancer.
Despite the resemblance of RIT1 to other members of the Ras small guanosine …
Despite the resemblance of RIT1 to other members of the Ras small guanosine …
Drugging the small GTPase pathways in cancer treatment: promises and challenges
Small GTPases are a family of low molecular weight GTP-hydrolyzing enzymes that cycle
between an inactive state when bound to GDP and an active state when associated to GTP …
between an inactive state when bound to GDP and an active state when associated to GTP …
Pathogenetics of the RASopathies
WE Tidyman, KA Rauen - Human molecular genetics, 2016 - academic.oup.com
The RASopathies are defined as a group of medical genetics syndromes that are caused by
germ-line mutations in genes that encode components or regulators of the Ras/mitogen …
germ-line mutations in genes that encode components or regulators of the Ras/mitogen …
PI3K/AKT signaling mediated by G protein‑coupled receptors is involved in neurodegenerative Parkinson's disease
N Nakano, S Matsuda, M Ichimura… - International …, 2017 - spandidos-publications.com
Parkinson's disease (PD) is a common progressive and multifactorial neurodegenerative
disease, characterized by the loss of midbrain dopaminergic neurons. Numerous …
disease, characterized by the loss of midbrain dopaminergic neurons. Numerous …
HIF-1α-induced RIT1 promotes liver cancer growth and metastasis and its deficiency increases sensitivity to sorafenib
Z Song, T Liu, J Chen, C Ge, F Zhao, M Zhu, T Chen… - Cancer letters, 2019 - Elsevier
Abstract Ras-like-without-CAAX-1 (RIT1) belongs to the RAS superfamily of small GTPases,
which plays critical roles in tumor progression. However, little is known about the roles of …
which plays critical roles in tumor progression. However, little is known about the roles of …
RIT1 regulates mitosis and promotes proliferation by interacting with SMC3 and PDS5 in hepatocellular carcinoma
Y Su, H Lin, J Yu, L Mao, W **, T Liu, S Jiang… - Journal of Experimental …, 2023 - Springer
Background As a small G protein of Ras family, Ras-like-without-CAAX-1 (RIT1) plays a
critical role in various tumors. Our previous study has demonstrated the involvement of RIT1 …
critical role in various tumors. Our previous study has demonstrated the involvement of RIT1 …
IGF-1 mediated Neurogenesis Involves a Novel RIT1/Akt/Sox2 Cascade
Insulin-like growth factor 1 (IGF-1) is known to have diverse effects on brain structure and
function, including the promotion of stem cell proliferation and neurogenesis in the adult …
function, including the promotion of stem cell proliferation and neurogenesis in the adult …