Covalent drugs have been used to treat diseases for more than a century, but tools that
facilitate the rational design of covalent drugs have emerged more recently. The purposeful …

Organoboron reagents represent a unique class of compounds because of their utility in
modern synthetic organic chemistry, often affording unprecedented reactivity. The …

Metalloenzymes are central to a wide range of essential biological activities, including
nucleic acid modification, protein degradation, and many others. The role of metalloenzymes …

A standard goal of medicinal chemists has been to discover efficient and potent drug
candidates with specific enzyme-inhibitor abilities. In this regard, boron-based bioactive …

Aminoacyl–transfer RNA (tRNA) synthetases, which catalyze the attachment of the correct
amino acid to its corresponding tRNA during translation of the genetic code, are proven …

Research related to boronic acids, from synthetic development to materials to drug
discovery, has skyrocketed in the past 20 years. In terms of drug discovery, the incorporation …

Tuberculosis is today amongst the worldwide health threats. As resistant strains of
Mycobacterium tuberculosis have slowly emerged, treatment failure is too often a fact …

Target-based drug discovery is the dominant paradigm of drug discovery; however, a
comprehensive evaluation of its real-world efficiency is lacking. Here, a manual systematic …

We report herein a simple, metal-and additive-free, photoinduced borylation of haloarenes,
including electron-rich fluoroarenes, as well as arylammonium salts directly to boronic acids …

The chemistry of organoelement compounds is now one of the most rapidly develo**
fields of research, regarding both fundamental science and solution of applied problems …