DNA topoisomerases are the targets of important anticancer and antibacterial drugs.
Camptothecins and novel noncamptothecins in clinical development (indenoisoquinolines …

Recent molecular studies have expanded the biological contexts in which topoisomerase II
(TOP2) has crucial functions, including DNA replication, transcription and chromosome …

Topoisomerases are ubiquitous enzymes that control DNA supercoiling and entanglements.
They are essential during transcription and replication, and topoisomerase inhibitors are …

Etoposide is an important chemotherapeutic agent that is used to treat a wide spectrum of
human cancers. It has been in clinical use for more than two decades and remains one of …

Topoisomerase II is an essential enzyme that is required for virtually every process that
requires movement of DNA within the nucleus or the opening of the double helix. This …

Topoisomerase 11 is an essential enzyme that plays a role in virtually every cellular DNA
process. This enzyme interconverts different topological forms of DNA by passing one …

Mitoxantrone is a synthetic anthracenedione originally developed to improve the therapeutic
profile of the anthracyclines and is commonly applied in the treatment of breast and prostate …

Topoisomerases play a pivotal role in ensuring DNA metabolisms during replication,
transcription and chromosomal segregation. To manage DNA topology, topoisomerases …

Topoisomerase poisons such as the epipodophyllotoxin etoposide are widely used effective
cytotoxic anticancer agents. However, they are associated with the development of therapy …

Etoposide is an antitumor agent currently in clinical use for the treatment of small cell lung
cancer, testicular cancer and lymphomas. Since the introduction of etoposide in 1971, its …