Many types of human cells self-destruct to maintain biological homeostasis and defend the
body against pathogenic substances. This process, called regulated cell death (RCD), is …

ABSTRACT Selenoprotein GPX4 (glutathione peroxidase 4), originally known as PHGPX
(phospholipid hydroperoxide glutathione peroxidase), is the main oxidoreductase in the use …

Caspases are proteolytic enzymes that belong to the cysteine protease family and play a
crucial role in homeostasis and programmed cell death. Caspases have been broadly …

Intracerebral hemorrhage (ICH) is a devastating form of stroke with high morbidity and
mortality. This review article focuses on the epidemiology, cause, mechanisms of injury …

The hallmark of tumorigenesis is the successful circumvention of cell death regulation for
achieving unlimited replication and immortality. Ferroptosis is a newly identified type of cell …

The immune response holds a pivotal role in cardiovascular disease development. As
multifunctional cells of the innate immune system, macrophages play an essential role in …

Innate immunity is the first response to protect against pathogens and cellular insults.
Pattern recognition receptors sense pathogen-and damage-associated molecular patterns …

Abstract Receptor-interacting protein kinase-3 (RIPK3, or RIP3) is an essential protein in the
“programmed” and “regulated” cell death pathway called necroptosis. Necroptosis is …

Reactive oxygen species (ROS) constitute a group of highly reactive molecules that have
evolved as regulators of important signaling pathways. It is now well accepted that moderate …

Stroke is the second leading cause of mortality and the major cause of adult physical
disability worldwide. The currently available treatment to recanalize the blood flow in acute …